Results 191 to 200 of about 616,085 (282)

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Materials and System Design for Self‐Decision Bioelectronic Systems

Advanced Materials, EarlyView.
This review highlights how self‐decision bioelectronic systems integrate sensing, computation, and therapy into autonomous, closed‐loop platforms that continuously monitor and treat diseases, marking a major step toward intelligent, self‐regulating healthcare technologies.
Qiankun Zeng, Hong Liu, Yongheng Zhang, Youbin Zheng, Xuyin Ding, Mengni Zhu, Guoyue Shi, Yan Wang, Hossam Haick, Min Zhang   +9 more
wiley   +1 more source

Low Arousal Positive Emotional Stimuli Attenuate Aberrant Working Memory Processing in Persons with Mild Cognitive Impairment

, 2017
Lucas S. Broster, Shonna Jenkins, Sarah Holmes, Gregory A. Jicha, Yang Jiang   +4 more
openalex   +1 more source

Recent Progress on Flexible Multimodal Sensors: Decoupling Strategies, Fabrication and Applications

Advanced Materials, EarlyView.
In this review, we establish a tripartite decoupling framework for flexible multimodal sensors, which elucidates the underlying principles of signal crosstalk and their solutions through material design, structural engineering, and AI algorithms. We also demonstrate its potential applications across environmental monitoring, health monitoring, human ...
Tao Wu, Yu‐Tao Li, Luyu Zhao, Yi Zhang, Zhaojie Zhang, Jian Yuan, Yiwen Wu, Anqi Che, Yuanxiao Ma, Yang Chai, Yeliang Wang   +10 more
wiley   +1 more source

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, EarlyView.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source

Intranasal administration of stem cell-derived exosome alleviates cognitive impairment against subarachnoid hemorrhage

S Gotoh, Masahito Kawabori, Sho Yamaguchi, Yo Nakahara, Erika Yoshie, Kohtarou Konno, Yuki Mizuno, Yoichiro Fujioka, Yusuke Ohba, Yuji Kuge, Masahiko Watanabe, Miki Fujimura   +11 more
openalex   +1 more source

Enhanced Trapping with an Optimized Graphene‐Based Bowtie Plasmonic Nanotweezer: Design, Analysis, and Bioanalytical Applications

Advanced Photonics Research, EarlyView.
A graphene‐based bowtie plasmonic nanotweezer is designed and optimized using particle swarm optimization and transfer matrix analysis. The structure achieves strong field confinement, delivering trapping forces up to 6 nN W−1 for 10 nm bioparticles with sixfold lower power requirements than conventional designs.
Saba Ebrahimpanah, Mohammad Hazhir Mozaffari, Ali Farmani   +2 more
wiley   +1 more source