Results 221 to 230 of about 641,525 (312)

Environmental noise in geriatric long-term care: Assessment of techniques targeting the reduction of behavior problems in cognitively impaired individuals [PDF]

, 1999
C. J. De Bruyn Kops, Y. L. McCurdy, B. Austin, N. Wecker, D. Kreger, M. Drexler   +5 more
openalex   +1 more source

Genetics‐Based Targeting Strategies for Precise Neuromodulation

Advanced Science, EarlyView.
In this Review, the fundamental principles and implementation protocols of genetics‐based precision neuromodulation are first introduced. Then, wireless and low‐invasive strategies based on nano‐transducing materials are highlighted, along with a dissection and analysis of the strengths and weaknesses of representative studies.
Yuyuan He, Zhidong Wei, Jianda Xu, Fei Jin, Tong Li, Lili Qian, Juan Ma, Weiying Zheng, Negar Javanmardi, Ting Wang, Kangjian Sun, Zhang‐Qi Feng   +11 more
wiley   +1 more source

A sexual consent and education assessment for the cognitively impaired [PDF]

, 1998
C.H. Kennedy
openalex   +1 more source

Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of TLR4 mRNA

Advanced Science, EarlyView.
Alzheimer's disease (AD) progression is influenced by microglia‐mediated neuroinflammation. Here, it is demonstrated that Listerin suppresses neuroinflammatory signaling and cognitive impairment in AD models by triggering IRE1α‐mediated TLR4 mRNA decay. Adenoviral Listerin delivery reduces amyloid‐β pathology, positioning it as a new therapeutic target.
Fei Qin, Runyu Cao, Xuemei Bai, Jiahua Yuan, Wanwei Sun, Yi Zheng, Xiaopeng Qi, Wei Zhao, Bingyu Liu, Chengjiang Gao   +9 more
wiley   +1 more source

The deletion allele of the angiotensin I converting enzyme gene as a genetic susceptibility factor for cognitive impairment

, 1996
Philippe Amouyel, Florence Richard, Dominique Cottel, Carole Amant, Valérie Codron, Nicole Helbecque   +5 more
openalex   +1 more source

Cognitive impairment and low blood pressure in the very old [PDF]

, 1997

openalex   +1 more source

Noninvasive Assessment of β‐Secretase Activity Through Click Chemistry‐Mediated Enrichment of Neuronal Extracellular Vesicles to Detect Alzheimer's Disease

Advanced Science, EarlyView.
This study presents the NEV β‐secretase activity assay, a groundbreaking method for noninvasive evaluation of β‐secretase activity in Alzheimer's disease (AD) patients, enabling the generation of individualized β‐secretase activity profiles.
Hyoyong Kim, Junseok Lee, Audrey Qian, You‐Ren Ji, Ryan Zhang, Qixin Hu, Christopher Kazu Williams, Han‐Yu Chuang, Matthew D. Smalley, Yaya Xu, Liang Gao, Mary C. Mayo, Ting Zhang, Edwin M. Posadas, Zaldy S. Tan, Harry V. Vinters, Keith Vossel, Shino Magaki, Yazhen Zhu, Hsian‐Rong Tseng   +19 more
wiley   +1 more source

S‐ketamine Alleviates Neuroinflammation and Attenuates Lipopolysaccharide‐Induced Depression Via Targeting SIRT2

Advanced Science, EarlyView.
S‐ketamine binds directly to SIRT2, facilitating its interaction with NF‐κB p65. This interaction reduces the acetylation of NF‐κB p65 and inhibits its activation, thereby exerting anti‐inflammatory and antidepressant effects. Created by BioRender.
Cong Lin, Xiaoxuan Zhou, Mingqi Li, Cong Zhang, Haojiang Zhai, Haohong Li, Hongshuang Wang, Xiaohui Wang   +7 more
wiley   +1 more source

Sleep Disturbance in Elderly Patients With Cognitive Impairment, Decreased Daily Activity and Periventricular White Matter Lesions

, 1995
Kenichi Meguro, M Ueda, Ichiro Kobayashi, Satoshi Yamaguchi, Hisato Yamazaki, Y. OIKAWA, Yoichi Kikuchi, H. Sasaki   +7 more
openalex   +1 more source

Regional metabolic patterns in mild cognitive impairment and Alzheimer’s disease [PDF]

, 2000
Kejal Kantarci, Clifford R. Jack, Yun Xu, Norberg G. Campeau, Peter C. O’Brien, Glenn E. Smith, Robert J. Ivnik, Bradley F. Boeve, E. Kokmen, Eric G. Tangalos, R. C. Petersen   +10 more
openalex   +1 more source