Results 41 to 50 of about 164,741 (262)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Towards a Coherent Theory of Project Alliancing: Discovering the System’s Complex Mechanisms Yielding Value for Money

Construction Economics and Building, 2017
Alliancing is a relatively new construction project delivery method receiving increasing interest globally while also eliciting many questions about its effectiveness.
Pertti Lahdenperä
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

From Cognitive Maps to Cognitive Graphs

PLoS ONE, 2014
We investigate the structure of spatial knowledge that spontaneously develops during free exploration of a novel environment. We present evidence that this structure is similar to a labeled graph: a network of topological connections between places, labeled with local metric information.
Chrastil, Elizabeth R, Warren, William H
openaire   +6 more sources

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Ranking residential neighborhoods based on their sustainability: a CM-BWM approach

International Journal of Strategic Property Management, 2022
Population growth and rapid urbanization have consequences that are reflected in the economic, environmental, and social stability of city-residential neighborhoods. These impacts directly affect not only residents but also real estate markets and local
Fábio M. C. Andrade, Fernando A. F. Ferreira, Ricardo J. C. Correia   +2 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

A heuristic framework to portray agroecological transition initiatives in reflexive arrangements, illustrated with a conservation agriculture network in Denmark

Ecology and Society
Agroecology has been proposed as an answer to the current global agri-food system crises. Transformation to agroecological agri-food systems can be enhanced through collaboration between societal agroecological initiatives and scientists in reflexive ...
Pauline Cassart, Anina Frei, Henrik Hauggaard-Nielsen, Henrik Kruse Rasmussen, Adrien Swartebroeckx, Eric Froidmont, Didier Stilmant, Walter A. H. Rossing   +7 more
doaj   +1 more source

Cognitive Maps

, 2001
A cognitive map is a representative expression of an individual's cognitive map knowledge, where cognitive map knowledge is an individual's knowledge about the spatial and environmental relations of geographic space. For example, a sketch map drawn to show the route between two locations is a cognitive map — a representative expression of the drawer's ...
openaire   +2 more sources