Results 71 to 80 of about 10,629,261 (299)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

The Effect of Breakfast and Snack Consumption on Children's Cognitive Performance [PDF]

, 2011
The current thesis aimed to investigate the effects of breakfast and snack on children’s cognitive performance. Chapter 1 presents an overview of cognitive development followed by a review of previous literature investigating the effects of breakfast and
Ingwersen, Jeanet, Ingwersen, Jeanet; id_orcid   +1 more
core   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

Re-Representing Metaphor: Modeling Metaphor Perception Using Dynamically Contextual Distributional Semantics

Frontiers in Psychology, 2019
In this paper, we present a novel context-dependent approach to modeling word meaning, and apply it to the modeling of metaphor. In distributional semantic approaches, words are represented as points in a high dimensional space generated from co ...
Stephen McGregor, Kat Agres, Karolina Rataj, Karolina Rataj, Matthew Purver, Geraint Wiggins, Geraint Wiggins   +6 more
doaj   +1 more source

Resting EEG, Hair Cortisol and Cognitive Performance in Healthy Older People with Different Perceived Socioeconomic Status

Brain Sciences, 2020
Successful aging depends upon several internal and external factors that influence the overall aging process. Objective and subjective socioeconomic status emerge as potential psychosocial factors in the ethiopathophysiology of aging-related disorders ...
Carolina Villada, Mauricio González-López, Herlinda Aguilar-Zavala, Thalía Fernández   +3 more
doaj   +1 more source

Use it or Lose it? What Predicts Age-Related Declines in Cognitive Performance in Elderly Adults? [PDF]

, 2004
Psychologists have suggested two possible causes of declines in cognitive performance with age: declines in cognitive capacity (e.g., working memory), and the level of stimulation in their environments.
Midkiff, Katherine
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Enhancing Cognitive Performance of Healthy Czech Seniors through Non-Native Language Learning—A Mixed-Methods Pilot Study

Brain Sciences, 2020
The aim of this article is to discuss the effect of learning a non-native language on the enhancement of cognitive performance in healthy native Czech elderly. In addition, special emphasis is put on the qualitative assessment.
Blanka Klimova, Gabriela Slaninova, Pavel Prazak, Jaroslav Kacetl, Martin Valis   +4 more
doaj   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Psychological, physical, and cognitive factors that influence tactical performance during a military relevant virtual reality scenario

Cognitive Research
Soldiers are challenged with interpreting information in unpredictable contexts, while maintaining high levels of job-specific performance. Virtual reality (VR) provides a controlled, immersive environment to evaluate military-relevant tasks under stress.
Jennifer N. Forse, Meaghan E. Beckner, Grace E. Giles, Tad T. Brunyé, Marianna D. Eddy, Julie A. Cantelon, Mathias Basner, Christopher Connaboy, Bradley C. Nindl   +8 more
doaj   +1 more source