Results 51 to 60 of about 10,629,261 (299)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A Scalable FPGA Architecture for Randomly Connected Networks of Hodgkin-Huxley Neurons

Frontiers in Neuroscience, 2018
Human intelligence relies on the vast number of neurons and their interconnections that form a parallel computing engine. If we tend to design a brain-like machine, we will have no choice but to employ many spiking neurons, each one has a large number of
Kaveh Akbarzadeh-Sherbaf, Behrooz Abdoli, Saeed Safari, Abdol-Hossein Vahabie   +3 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Cognitive performance in patients with COPD [PDF]

Respiratory Medicine, 2004
Hypoxemic patients with Chronic Obstructive Pulmonary Disease (COPD) have impaired cognitive performance. These neuropsychological impairments are related to the degree of hypoxemia. So far, cognitive performance has not been tested in non-hypoxemic patients with COPD.We recruited patients with stable COPD and PaO2 > 8.0 kPa (60 mmHg), as well as ...
Liesker, JJW, Postma, DS, Beukema, RJ, ten Hacken, NHT, van der Molen, T, Riemersma, RA, van Zomeren, EH, Kerstjens, HAM   +7 more
openaire   +3 more sources

Offloading Cognition onto Cognitive Technology [PDF]

, 2008
"Cognizing" (e.g., thinking, understanding, and knowing) is a mental state. Systems without mental states, such as cognitive technology, can sometimes contribute to human cognition, but that does not make them cognizers.
Dror, I, Harnad, S, Stevan Harnad, Itiel E. Dror, Dror, Itiel, Harnad, Stevan   +5 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Challenges and insights of transferring animal maze studies principles to human spatial learning research

Scientific Reports
Maze tasks, originally developed in animal research, have become a popular method for studying human cognition, particularly with the advent of virtual reality.
Piruza Manukyan, Elizaveta Romanova, Alexander Latanov, Pavel Shlepnev, Anastasia Sharapkova, Naida Garabova, Vladimir Kasatkin, Vera Tolchennikova   +7 more
doaj   +1 more source

Dietary nitrate modulates cerebral blood flow parameters and cognitive performance in humans: A double-blind, placebo-controlled, crossover investigation [PDF]

, 2015
Nitrate derived from vegetables is consumed as part of a normal diet and is reduced endogenously via nitrite to nitric oxide. It has been shown to improve endothelial function, reduce blood pressure and the oxygen cost of sub-maximal exercise, and ...
Haskell, Crystal, Winyard, Paul, Kennedy, David, Blackwell, Jamie, Blackwell, James, Thompson, Kevin, Wightman, Emma, Forster, Joanne, Jones, Andrew, Haskell-Ramsay, Crystal   +9 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source