Results 181 to 190 of about 308,966 (305)

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Cognitive Profile in Parkinson's Disease Dementia Patients with Low versus Normal Cerebrospinal Fluid Amyloid Beta. [PDF]

Dement Geriatr Cogn Dis Extra, 2023
Tufekcioglu Z, Lange J, Pedersen KF, Tysnes OB, Alves G, Emre M.   +5 more
europepmc   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Correction: Cognitive profile and frailty in patients with idiopathic normal pressure hydrocephalus. [PDF]

Front Neurol
Dejgaard MS, Eide PK, Tangen GG, Skovlund E, Selbæk G, Wyller TB.   +5 more
europepmc   +1 more source

Impact of SNR, peripheral auditory sensitivity, and central cognitive profile on the psychometric relation between pupillary response and speech performance in CI users. [PDF]

Front Neurosci, 2023
Zhang Y, Callejón-Leblic MA, Picazo-Reina AM, Blanco-Trejo S, Patou F, Sánchez-Gómez S.   +5 more
europepmc   +1 more source

Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome

Advanced Science, EarlyView.
We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu, Shuhao Chen, Yunheng Diao, Wei Wang, Yuanyuan Huang, Liqin Liang, Xiaodan Lu, Rui Han, Minxin Guo, Zhaobo Li, Shuhong Wang, Hehua Li, Chenyu Liu, Jing Zhou, Dongsheng Xiong, Xiaobo Li, Yuping Ning, Xuetao Shi, Fengchun Wu, Kai Wu   +19 more
wiley   +1 more source

Reply to Fitzgerald et al.: Mischaracterizing our findings; the cognitive profile of elite footballers remains robust. [PDF]

Proc Natl Acad Sci U S A
Bonetti L, Vestberg T, Jafari R, Seghezzi D, Ingvar M, Kringelbach ML, Filgueiras A, Petrovic P.   +7 more
europepmc   +1 more source

The cognitive profile of Friedreich ataxia: a systematic review and meta-analysis. [PDF]

BMC Neurol, 2022
Naeije G, Schulz JB, Corben LA.
europepmc   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Cognitive profile of psychiatric patients with coexisting enlarged ventricles and cognitive impairment: A rare cross-diagnostic phenotype predominantly observed in schizophrenia. [PDF]

Psychiatry Clin Neurosci
Matsumoto J, Ito S, Sumiyoshi C, Yasuda Y, Hasegawa N, Fujimoto M, Yamamori H, Sumiyoshi T, Hashimoto R.   +8 more
europepmc   +1 more source