Results 51 to 60 of about 2,095,514 (288)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Les formes symboliques artistiques au prisme de la musique : pour une approche trans-sémiotique
Signata, 2017 This article takes up the project of E. Cassirer, proposing to think of his Philosophy of symbolic forms as a both federative and differential trans-semiotic.
Lia Kurts-Wöste
doaj +1 more source
Phenomena and Objects of Research in the Cognitive and Behavioral Sciences [PDF]
, 2017 It is commonly held that research efforts in the cognitive and behavioral sciences are mainly directed toward providing explanations and that phenomena figure into scientific practice qua explananda.
Feest, Uljana
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
What is Strategic Competence and Does it Matter? Exposition of the Concept and a Research Agenda [PDF]
, 2006 Drawing on a range of theoretical and empirical insights from strategic management and the cognitive and organizational sciences, we argue that strategic competence constitutes the ability of organizations and the individuals who operate within them to ...
Hodgkinson, Gerard P. +1 more
core +2 more sources
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
From Movement to Sound, from Sound to Movement: biocultural relations between dance and music
Revista Brasileira de Estudos da Presença, 2020 This article discusses the interactions between body and sound in the creative process characterized by the relation between dance, music and sonic experiments.
Andréia Nhur
doaj
Content analysis of techniques and methods used in cognitive science journals
مجله علوم روانشناختی, 2022 Background: Cognitive science is an interdisciplinary field whose methodology is less developed in the form of books or independent articles and there are many problems in its methodological field.
nadia Soltani +5 more
doaj
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source