Results 141 to 150 of about 463,034 (316)

Early cortical surface plasticity relates to basic mathematical learning

open access: yesNeuroImage, 2020
Children lay the foundation for later academic achievement by acquiring core mathematical abilities in the first school years. Neural reorganization processes associated with individual differences in early mathematical learning, however, are still ...
Ulrike Kuhl   +15 more
doaj  

Picomolar Detection of Tau Protein Using 1D Photonic Crystal Biochips for Alzheimer's Disease Diagnosis

open access: yesAdvanced Sensor Research, EarlyView.
Elevated levels of Tau in cerebrospinal fluids or other body fluids are associated with the progression of Alzheimer's disease. An optical technique, based on a dual label‐free and fluorescence operation mode, is developed to detect Tau protein in both standard running buffer and cerebrospinal fluid.
Alberto Sinibaldi   +7 more
wiley   +1 more source

Advances in Microfluidic Cochlea‐On‐A‐Chip

open access: yesAdvanced Science, EarlyView.
This review systematically examines diverse cell sources for inner ear organoids and outlines stepwise induction protocols. Furthermore, it discusses current applications and prospective developments of cochlea‐on‐a‐chip technologies in areas such as deafness modeling, mechanistic studies, and drug evaluation, with particular focus on gene‐therapy drug
Tian Shen   +10 more
wiley   +1 more source

Building strength for the long haul toward liberation: What psychology can contribute to the resilience of communities targeted by state‐sanctioned violence

open access: yesAmerican Journal of Community Psychology, Volume 70, Issue 3-4, Page 475-492, December 2022., 2022
Abstract State‐sanctioned violence (SSV) has resounding effects on entire populations, and marginalized communities have long persisted in the work toward liberation despite continued SSV. This paper aims to bridge the gap between the vast scholarship on resilience and the practical challenge of sustaining and thriving in communities targeted by SSV ...
Kris T. Gebhard   +4 more
wiley   +1 more source

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

open access: yesAdvanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei   +15 more
wiley   +1 more source

A phase 1b study of venetoclax and azacitidine combination in patients with relapsed or refractory myelodysplastic syndromes

open access: yesAmerican Journal of Hematology, Volume 98, Issue 2, Page 272-281, February 2023., 2023
Abstract Patients with relapsed/refractory (R/R) higher‐risk myelodysplastic syndromes (MDS) have a dismal median overall survival (OS) after failing hypomethylating agent (HMA) treatment. There is no standard of care for patients after HMA therapy failure; hence, there is a critical need for effective therapeutic strategies.
Amer M. Zeidan   +18 more
wiley   +1 more source

PATIENT-Ψ: Using Large Language Models to Simulate Patients for Training Mental Health Professionals [PDF]

open access: yesarXiv
Mental illness remains one of the most critical public health issues. Despite its importance, many mental health professionals highlight a disconnect between their training and actual real-world patient practice. To help bridge this gap, we propose PATIENT-{\Psi}, a novel patient simulation framework for cognitive behavior therapy (CBT) training.
arxiv  

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