Results 151 to 160 of about 5,622,406 (301)

Why Do Low-Educated Workers Invest Less in Further Training? [PDF]

Several studies document the fact that low-educated workers participate less often in further training than high-educated workers. The economic literature suggests that there is no significant difference in employer willingness to train low-educated ...
Schils, Trudie, de Grip, Andries, Fouarge, Didier   +2 more
core  

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Advanced Science, EarlyView.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +1 more source

Effects of a Cognitive-Physical Dual-Task Training Program on Cognitive Function among Middle-Aged and Older Adults With Subjective Cognitive Decline: A Pilot Study

Subjective cognitive decline (SCD) is a preclinical stage associated with an increased risk for future cognitive impairment. This study aimed to investigate the effects of a combined cognitive-physical training program on cognitive function in middle ...
Sung-Chul Jun, Gowoon Jung, Young-Hyeon Bae, The Korean Society of Cognitive Therapeutic Exercise, Seung Hee Ho, Hyun-Seok Hwang, Bora Kang, Ju-Hee Kim, Jihyun Yoo   +8 more
core   +1 more source

An On‐Demand Neuromorphic Vision System Enabled by a Multi‐Paradigm Neuromorphic Device and Hierarchical Reconfigurability Designed from Device to System Level

Advanced Science, EarlyView.
An on‐demand ultra‐reconfigurable intelligent vision system with hierarchical reconfigurability from device to system levels is demonstrated. Through co‐design of a multi‐paradigm device, reconfigurable circuits, and adaptive system architecture/algorithms, the system enables seamless switching among spiking, non‐spiking, neuromorphic imaging (NI), and
Biyi Jiang, Jiayi Xu, Liang Ran, Xinhe Feng, Khalil Harrabi, Yida Li, Longyang Lin, Feichi Zhou   +7 more
wiley   +1 more source

Biennial Reports of the State Hospital for Epileptics at Parsons, Parsons State Training School, and Parsons State Hospital and Training Center, 1903/04-1957/58.

, 1904
1903/04 (1st)-1951/52 (25th) Biennial Reports issued by the State Hospital for Epileptics 1953/54 (26th)-1955/56 (27th) Biennial Reports issued by: Parsons State Training School 1957/58 (28th) Biennial Report issued by: Parsons State Hospital and ...
Parsons State Hospital and Training Center.
core   +1 more source

Situated cognitive engineering : the requirements and design of directed scenario-based training

, 2011
The development of adaptive virtual learning environments as an educative tool is promising. In this paper we use the situated cognitive engineering method to analyze the operational demands, theoretical foundations and technological opportunities for ...
Bosch, K. van den, Meyer, J.J.C., Neerincx, M.A., Peeters, M.   +3 more
core  

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Resting state brain activity and association with transfer of cognitive training gains. [PDF]

Neuroimage Rep
Faraza S, Dyrba M, Wolf D, Fischer FU, Knaepen K, Riedel D, Kollmann B, Binder H, Mierau A, Fellgiebel A, Tüscher O, Teipel S, German AgeGain Study Group.   +12 more
europepmc   +1 more source