Results 41 to 50 of about 5,285,152 (201)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Coherence and catalysis in the Jaynes–Cummings model

New Journal of Physics, 2020
There has been substantial interest of late on the issue of coherence as a resource in quantum thermodynamics. To date, however, analyses have focused on somewhat artificial theoretical models.
Anette Messinger, Atirach Ritboon, Frances Crimin, Sarah Croke, Stephen M Barnett   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Entangled coherent states by mixing squeezed vacuum and coherent light

, 2017
Entangled coherent states are shown to emerge, with high fidelity, when mixing coherent and squeezed vacuum states of light on a beam-splitter.
Lior Cohen (6663407), Yonatan Israel (3697060), Jaewoo Joo (6663413), Hagai S. Eisenberg (2564923), Xin-Bing Song (6663410), Yaron Silberberg (3697057)   +5 more
core   +1 more source

Weak Force Detection with Superposed Coherent States [PDF]

, 2002
We investigate the utility of non classical states of simple harmonic oscillators, particularly a superposition of coherent states, for sensitive force detection.
Milburn, G. J., Braunstein, S. L., Munro, W. J., Nemoto, K., Milburn, Gerard J.   +4 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Coherent States for Tremblay-Turbiner-Winternitz Potential

Symmetry, Integrability and Geometry: Methods and Applications, 2012
In this study, we construct the coherent states for a particle in the Tremblay-Turbiner-Winternitz potential by finding the conserved charge coherent states of the four harmonic oscillators in the polar coordinates.
Yusuf Sucu, Nuri Unal
doaj   +1 more source

Teleportation via an Entangled Coherent Channel and Decoherence Effect on This Channel [PDF]

Journal of Optoelectronical Nanostructures, 2019
We study an entangled two-mode coherent state within the framework of2×2-dimensional Hilbert space. We investigate the problem of quantum teleportation ofa superposition coherent state via an entangled coherent channel.
Ardalan Fatahizadeh, Ardeshir Rabeie
doaj  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source