Results 111 to 120 of about 6,267,604 (379)

Developing managers as researchers using a learning cohort approach [PDF]

, 2010
This paper describes the design process and curriculum for a learning cohort of eight managers who came from public and private providers of vocational education and training.
Choy, Sarojni, Delahaye, Brian, Saggers, Beth   +2 more
core   +1 more source

Another 'futile quest'? A simulation study of Yang and Land's Hierarchical Age-Period-Cohort model [PDF]

, 2013
Background: Whilst some argue that a solution to the age-period-cohort (APC) 'identification problem' is impossible, numerous methodological solutions have been proposed, including Yang and Land's Hierarchical-APC (HAPC) model: a multilevel model ...
Bell, Andrew, Jones, Kelvyn
core   +4 more sources

The Generation R Study: design and cohort update 2017

European Journal of Epidemiology, 2016
The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and ...
Marjolein N. Kooijman, Claudia J. Kruithof, C. V. van Duijn, L. Duijts, O. Franco, Marinus H. van IJzendoorn, J. D. de Jongste, C. Klaver, A. van der Lugt, J. Mackenbach, H. Moll, R. Peeters, H. Raat, E. Rings, F. Rivadeneira, M. P. van der Schroeff, E. Steegers, H. Tiemeier, A. Uitterlinden, F. Verhulst, E. Wolvius, J. Felix, V. Jaddoe   +22 more
semanticscholar   +1 more source

Cohort Profile: The Nigerian HIV Geriatric Cohort Study [PDF]

BMC Public Health, 2019
Abstract Background: An estimated 280,000 adults aged 50 years and above live with HIV in Nigeria, a population set to increase with ART efficacy and expanding coverage. To learn how elderly people living with HIV (EPLHIV) in Nigeria fare, despite not being prioritized by the national treatment program, and to deepen knowledge for their ...
Dakum, P, Avong, YK, Odutola, MK, Okuma, J, Kayode, GA, Nta, IE, Ndembi, N, Mensah, C, Khamofu, H, Okonkwo, P, Okpanachi, JO, Ezeanolue, E   +11 more
openaire   +5 more sources

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

BMI and all cause mortality: systematic review and non-linear dose-response meta-analysis of 230 cohort studies with 3.74 million deaths among 30.3 million participants

British medical journal, 2016
Objective To conduct a systematic review and meta-analysis of cohort studies of body mass index (BMI) and the risk of all cause mortality, and to clarify the shape and the nadir of the dose-response curve, and the influence on the results of confounding ...
D. Aune, A. Sen, M. Prasad, T. Norat, I. Janszky, S. Tonstad, P. Romundstad, L. Vatten   +7 more
semanticscholar   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Limb muscle mass and phase angle asymmetry in 8-year-old children

Scientific Reports
Little is known about phase angle (PhA), a bioelectrical impedance analysis (BIA) indicator of cellular health, and muscle asymmetry in the limbs of children. The purpose of this study is to clarify PhA and muscle mass asymmetry in the limbs of children.
Masanori Wako, Taro Fujimaki, Jiro Ichikawa, Ryoji Shinohara, Sanae Otawa, Anna Kobayashi, Megumi Kushima, Hideki Yui, Zentaro Yamagata, Hirotaka Haro, Yamanashi Adjunct Study of the Japan Environment, Children’s Study Group   +10 more
doaj   +1 more source