Results 41 to 50 of about 6,160,931 (240)
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera +11 morewiley +1 more sourceCohort Profile: The Canadian Longitudinal Study on Aging (CLSA)
International Journal of Epidemiology, 2019 • A submitted manuscript is the version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to Parminder Raina, Parminder Raina, Christina Wolfson, Christina Wolfson, S. Kirkland, Lauren E Griffith, Lauren E Griffith, C. Balion, B. Cossette, I. Dionne, S. Hofer, David B. Hogan, E. R. V. D. Heuvel, T. Liu-Ambrose, V. Menec, Gerald Mugford, Christopher Patterson, H. Payette, B. Richards, H. Shannon, D. Sheets, V. Taler, Mary Thompson, H. Tuokko, A. Wister, Changbao Wu, Lynne Young +26 moresemanticscholar +1 more sourceTumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini +12 morewiley +1 more sourceThe Parkinson's progression markers initiative (PPMI) – establishing a PD biomarker cohort
Annals of Clinical and Translational Neurology, 2018 The Parkinson's Progression Markers Initiative (PPMI) is an observational, international study designed to establish biomarker‐defined cohorts and identify clinical, imaging, genetic, and biospecimen Parkinson's disease (PD) progression markers to ...K. Marek, S. Chowdhury, A. Siderowf, Shirley Lasch, C. Coffey, C. Caspell-Garcia, T. Simuni, D. Jennings, C. Tanner, J. Trojanowski, L. Shaw, J. Seibyl, N. Schuff, A. Singleton, K. Kieburtz, A. Toga, B. Mollenhauer, D. Galasko, L. Chahine, D. Weintraub, T. Foroud, D. Tosun-Turgut, K. Poston, V. Arnedo, M. Frasier, T. Sherer, S. Bressman, M. Merchant, W. Poewe, C. Kopil, A. Naito, R. Dorsey, C. Casaceli, N. Daegele, J. Albani, L. Uribe, Eric D. Foster, J. Long, N. Seedorff, K. Crawford, Danielle Smith, P. Casalin, G. Malferrari, C. Halter, L. Heathers, D. Russell, S. Factor, P. Hogarth, A. Amara, R. Hauser, J. Jankovic, M. Stern, Shu‐Ching Hu, Gretchen Todd, R. Saunders-Pullman, I. Richard, H. Saint‐Hilaire, K. Seppi, H. Shill, Hubert H. Fernandez, C. Trenkwalder, W. Oertel, D. Berg, Kathrin Brockman, I. Wurster, L. Rosenthal, Yen F. Tai, N. Pavese, P. Barone, S. Isaacson, A. Espay, D. Rowe, M. Brandabur, J. Tetrud, G. Liang, Á. Iranzo, E. Tolosa, K. Marder, Maria de Sanchez, L. Stefanis, M. Marti, J. Martínez, J. Corvol, O. Assly, Salima Brillman, Nir Giladi, Debra Smejdir, Julia Pelaggi, F. Kausar, L. Rees, Barbara Sommerfield, Madeline Cresswell, C. Blair, Karen Williams, Grace A. Zimmerman, S. Guthrie, Ashlee Rawlins, Leigh Donharl, C. Hunter, B. Tran, A. Darin, Heli A. Venkov, Cathi A Thomas, Raymond James, B. Heim, Paul Deritis, F. Sprenger, D. Raymond, D. Willeke, Zoran Obradov, J. Mule, Nancy Monahan, K. Gauss, D. Fontaine, D. Szpak, Arita McCoy, Becky Dunlop, Laura Payne, Susan Ainscough, L. Carvajal, Rebecca Silverstein, Kristy J. Espay, Madelaine B. Rañola, E. Rezola, H. Santana, M. Stamelou, Alicia Garrido, S. Carvalho, G. Kristiansen, Krista Specketer, Anat Mirlman, M. Facheris, H. Soares, A. Mintun, J. Cedarbaum, Peggy Taylor, L. Slieker, Brian McBride, Colin Watson, Etienne Montagut, Z. Sheikh, Baris Bingol, R. Forrat, P. Sardi, T. Fischer, D. Reith, J. Egebjerg, L. Larsen, N. Breysse, D. Meulien, B. Saba, V. Kiyasova, C. Min, Thomas McAvoy, R. Umek, P. Iredale, J. Edgerton, Demetrio Santi, C. Czech, F. Boess, J. Sevigny, T. Kremer, I. Grachev, K. Merchant, A. Avbersek, P. Muglia, Alexandra Stewart, R. Prashad, Johannes Taucher +168 moresemanticscholar +1 more sourceMetabolic Syndrome Derived from Principal Component Analysis and Incident Cardiovascular Events: The Multi Ethnic Study of Atherosclerosis (MESA) and Health, Aging, and Body Composition (Health ABC). [PDF]
, 2012 Background. The NCEP metabolic syndrome (MetS) is a combination of dichotomized interrelated risk factors from predominantly Caucasian populations. We propose a continuous MetS score based on principal component analysis (PCA) of the same risk factors in Agarwal, Subhashish, Andrews, Jeanette S, Chen, Yii-Der Ida, Goodpaster, Bret, Herrington, David M, Jacobs, David R, Jorgensen, Neal W, Kanaya, Alka, Kritchevsky, Stephen, Liu, Yongmei, Newman, Anne B, Rotter, Jerome I, Sibley, Christopher T, Simonsick, Eleanor M, Vaidya, Dhananjay +14 morecore +4 more sourcesCohort profile: the National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS) in Korea
BMJ Open, 2017 Purpose The National Health Insurance Service-Health Screening Cohort (NHIS-HEALS) is a cohort of participants who participated in health screening programmes provided by the NHIS in the Republic of Korea.S. Seong, Yeon-Yong Kim, Sue-Kyung Park, Y. Khang, H. Kim, Jong Heon Park, Hee-Jin Kang, Cheol-Ho Do, Jong-Sun Song, Eun-Joo Lee, Seongjun Ha, S. Shin, Seung-lyeal Jeong +12 moresemanticscholar +1 more sourceGlycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala +18 morewiley +1 more sourceRisk Model Development and Validation for Prediction of Coronary Artery Aneurysms in Kawasaki Disease in a North American Population. [PDF]
, 2019 Background Accurate prediction of coronary artery aneurysms ( CAAs ) in patients with Kawasaki disease remains challenging in North American cohorts. We sought to develop and validate a risk model for CAA prediction.Baker, Annette L, Burns, Jane C, de Ferranti, Sarah, Dedeoglu, Fatma, Friedman, Kevin G, Gauvreau, Kimberlee, Lo, Mindy, Newburger, Jane W, Son, Mary Beth F, Sundel, Robert P, Tremoulet, Adriana H +10 morecore