Results 81 to 90 of about 623,379 (248)

Cerebrospinal Fluid Liquid Biopsy Enables Targeted Therapy Without Tissue Diagnosis in Pediatric Low‐Grade Gliomas With BRAF V600E Mutation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We present two pediatric cases of pediatric low‐grade gliomas (PLGG) with BRAF V600E mutations diagnosed and monitored using cerebrospinal fluid (CSF) liquid biopsy analyzed via digital droplet PCR (ddPCR), without tissue biopsy. Both patients were treated with dabrafenib and trametinib and monitored through clinical assessments, magnetic ...
Hannah Sultan, Damien Faury, Alexander G. Weil, Harrison J. Westwick, Nada Jabado, Sébastien Perreault   +5 more
wiley   +1 more source

Changes in Body Composition in Children and Young People Undergoing Treatment for Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed, Raquel Revuelta Iniesta, Mary Fewtrell, Julie Lanigan, Breeana Gardiner, Graeme O'Connor   +5 more
wiley   +1 more source

Prolonged Corrected QT Interval as an Early Electrocardiographic Marker of Cyclophosphamide‐Induced Cardiotoxicity in Pediatric Hematology and Oncology Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cyclophosphamide (CY) is associated with potentially fatal cardiotoxicity, yet no electrocardiographic indices have been established for early detection of CY‐induced cardiomyopathy. This study aimed to determine whether corrected QT interval (QTc) prolongation can predict early onset of CY‐related cardiac dysfunction in pediatric ...
Junpei Kawamura, Kentaro Ueno, Takuro Nishikawa, Yoshihiro Takahashi, Koji Nakae, Yasuhiro Okamoto   +5 more
wiley   +1 more source

Predicting Chronicity in Children and Adolescents With Newly Diagnosed Immune Thrombocytopenia at the Timepoint of Diagnosis Using Machine Learning‐Based Approaches

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser, Alice Bizeul, Meera Chitlur, Hugo Donato, Jelena Roganovic, Julia E. Vogt, Thomas Kühne   +6 more
wiley   +1 more source

Limb muscle mass and phase angle asymmetry in 8-year-old children

Scientific Reports
Little is known about phase angle (PhA), a bioelectrical impedance analysis (BIA) indicator of cellular health, and muscle asymmetry in the limbs of children. The purpose of this study is to clarify PhA and muscle mass asymmetry in the limbs of children.
Masanori Wako, Taro Fujimaki, Jiro Ichikawa, Ryoji Shinohara, Sanae Otawa, Anna Kobayashi, Megumi Kushima, Hideki Yui, Zentaro Yamagata, Hirotaka Haro, Yamanashi Adjunct Study of the Japan Environment, Children’s Study Group   +10 more
doaj   +1 more source

A Systematic Review of Evidence on the Clinical Effectiveness of Surveillance Imaging in Children With Medulloblastoma and Ependymoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Surveillance imaging aims to detect tumour relapse before symptoms develop, but it's unclear whether earlier detection of relapse leads to better outcomes in children and young people (CYP) with medulloblastoma and ependymoma. This systematic review aims to identify relevant literature to determine the efficacy of surveillance magnetic ...
Lucy Shepherd, Melissa Taylor, Helen Fulbright, Bob Phillips   +3 more
wiley   +1 more source

Early life vitamin D status and asthma and wheeze: a systematic review and meta-analysis

BMC Pulmonary Medicine, 2018
Background Vitamin D deficiency has been linked to an increased risk of asthma. This study aimed to quantify the effect of early life vitamin D status on asthma and wheeze later in life.
Song-Ying Shen, Wan-Qing Xiao, Jin-Hua Lu, Ming-Yang Yuan, Jian-Rong He, Hui-Min Xia, Xiu Qiu, Kar Keung Cheng, Kin Bong Hubert Lam   +8 more
doaj   +1 more source

Hepatocellular Carcinoma Demonstrates Heterogeneous Growth Patterns in a Multicenter Cohort of Patients With Cirrhosis [PDF]

, 2020
Nicole E. Rich, Binu V. John, Neehar D. Parikh, Ian Rowe, Neil Mehta, Gaurav Khatri, Smitha Thomas, Munazza Anis, Mishal Mendiratta‐Lala, Christopher Hernandez, Mobolaji Odewole, Latha Thankam Sundaram, Venkata Rajesh Konjeti, Shishir Shetty, Tahir Shah, Hao Zhu, Adam C. Yopp, Yujin Hoshida, Francis Y. Yao, Jorge A. Marrero, Amit G. Singal   +20 more
openalex   +1 more source

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

Genetic and environmental variation in educational attainment: an individual-based analysis of 28 twin cohorts [PDF]

, 2020
Karri Silventoinen, Aline Jelenkovic, Reijo Sund, Antti Latvala, Chika Honda, Fujio Inui, Rie Tomizawa, Mikio Watanabe, Norio Sakai, Esther Rebato, Andreas Busjahn, Jessica Tyler, John L. Hopper, Juan R. Ordoñana, Juan F. Sánchez-Romera, Lucía Colodro‐Conde, Lucas Calais‐Ferreira, Vinícius Cunha Oliveira, Paulo H. Ferreira, Emanuela Medda, Lorenza Nisticò, Virgilia Toccaceli, Cathérine Derom, Robert Vlietinck, Ruth J. F. Loos, Sisira Siribaddana, Matthew Hotopf, Athula Sumathipala, Frühling Rijsdijk, Glen E. Duncan, Dedra Buchwald, Per Tynelius, Finn Rasmussen, Qihua Tan, Dongfeng Zhang, Zengchang Pang, Patrik K. E. Magnusson, Nancy L. Pedersen, Anna K. Dahl Aslan, Amie E. Hwang, Thomas M. Mack, Robert F. Krueger, Matt McGue, Shandell Pahlen, Ingunn Brandt, Thomas Sevenius Nilsen, Jennifer R. Harris, Nicholas G. Martin, Sarah E. Medland, Grant W. Montgomery, Gonneke Willemsen, Meike Bartels, Maties Torrent, Carol E. Franz, William S. Kremen, Michael J. Lyons, Judy L. Silberg, Hermine H. Maes, Christian Kandler, Tracy L. Nelson, Keith E. Whitfield, Robin P. Corley, Brooke M. Huibregtse, Margaret Gatz, David A. Butler, Ádám Domonkos Tárnoki, Dávid László Tárnoki, Hang A Park, Jooyeon Lee, Soo Ji Lee, Joohon Sung, Yoshie Yokoyama, Thorkild I. A. Sørensen, Dorret I. Boomsma, Jaakko Kaprio   +74 more
openalex   +1 more source