Results 91 to 100 of about 43,381,677 (339)

Skeletal muscle mass to visceral fat area ratio as a predictor of NAFLD in lean and overweight men and women with effect modification by sex

Hepatology Communications, 2022
The effect of sarcopenic visceral obesity on the risk of nonalcoholic fatty liver disease (NAFLD) is uncertain. We investigated (a) whether the skeletal muscle mass to visceral fat area ratio (SV ratio), as a measure of sarcopenic visceral obesity, is a ...
Yoosun Cho, Yoosoo Chang, Seungho Ryu, Hyun‐Suk Jung, Chan‐won Kim, Hyungseok Oh, Mi Kyung Kim, Won Sohn, Hocheol Shin, Sarah H. Wild, Christopher D. Byrne   +10 more
doaj   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Sex-specific association between carbohydrate antigen 19–9 and incident type 2 diabetes

Scientific Reports
Carbohydrate antigen 19–9 (CA19-9) levels are associated with glycemic control, insulin resistance, and chronic complications in patients with type 2 diabetes (T2D). Women generally show higher CA19-9 levels despite a greater T2D prevalence in men.
Sujeong Shin, Yoosoo Chang, Seungho Ryu
doaj   +1 more source

Magnitude of problematic anger and its predictors in the Millennium Cohort

BMC Public Health, 2020
Background Problematic anger is intense anger associated with elevated generalized distress and that interferes with functioning. It also confers a heightened risk for the development of mental health problems.
Amy B. Adler, Cynthia A. LeardMann, Kimberly A. Roenfeldt, Isabel G. Jacobson, David Forbes, for the Millennium Cohort Study Team   +5 more
doaj   +1 more source

Cohort Profile: The UK Women’s Cohort Study (UKWCS) [PDF]

International Journal of Epidemiology, 2015
Cohort Profile: The UK Women’s Cohort Study (UKWCS) Janet E Cade,* Victoria J Burley, Nisreen A Alwan, Jayne Hutchinson, Neil Hancock, Michelle A Morris, Diane E Threapleton and Darren C Greenwood School of Food Science and Nutrition, Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK, Department of Health ...
Cade, Janet E., Burley, Victoria J., Alwan, Nisreen A., Hutchinson, Jayne, Hancock, Neil, Morris, Michelle A., Threapleton, Diane E., Greenwood, Darren C.   +7 more
openaire   +5 more sources

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

The growth and development of cohort studies

Annals of Human Biology, 2020
Cohort studies are special forms of longitudinal studies that have long been accepted as the primary designs to acquire information on the interaction between the environment and health and the subsequent aetiology and progression of disease.
Noël Cameron
doaj   +1 more source

Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality: dose–response meta-analysis of prospective cohort studies

European Journal of Epidemiology, 2017
With a growing number of prospective cohort studies, an updated dose–response meta-analysis of milk and dairy products with all-cause mortality, coronary heart disease (CHD) or cardiovascular disease (CVD) have been conducted.
Jing Guo, A. Astrup, J. Lovegrove, L. Gijsbers, D. Givens, S. Soedamah-Muthu   +5 more
semanticscholar   +1 more source

Cohort Profile: The Limache, Chile, birth cohort study [PDF]

International Journal of Epidemiology, 2013
The Limache cohort was set up to assess the programming and life course events hypotheses in relation to cardiovascular risk factors and chronic respiratory conditions, especially asthma, in the context of an unprecedented economic growth in Chile. The cohort was a representative sample of 1232 participants born between 1974 and 1978 in the hospital of
Amigo, Hugo, Bustos, Patricia, Zumelzú, Elinor, Rona, Roberto J.   +3 more
openaire   +4 more sources

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source