Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value
Molecular Oncology, EarlyView.The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song +13 more
wiley +1 more source
Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
Molecular Oncology, EarlyView.We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi +26 more
wiley +1 more source
Generating patient cohorts from electronic health records using two-step retrieval-augmented text-to-SQL generation [PDF]
arXivClinical cohort definition is crucial for patient recruitment and observational studies, yet translating inclusion/exclusion criteria into SQL queries remains challenging and manual. We present an automated system utilizing large language models that combines criteria parsing, two-level retrieval augmented generation with specialized knowledge bases ...
arxiv
Cohort Profile: The Doetinchem Cohort Study [PDF]
International Journal of Epidemiology, 2008 Henriette A. Smit +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé +7 more
wiley +1 more source
CohortNet: Empowering Cohort Discovery for Interpretable Healthcare Analytics [PDF]
arXivCohort studies are of significant importance in the field of healthcare analysis. However, existing methods typically involve manual, labor-intensive, and expert-driven pattern definitions or rely on simplistic clustering techniques that lack medical relevance.
arxiv
A cohort study of psychosurgery cases from a defined population. [PDF]
, 1988 Ehtisham Hussain +2 more
openalex +1 more source
Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
Molecular Oncology, EarlyView.CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak +14 more
wiley +1 more source
Home and Mortgage Ownership of the Dutch Elderly: Explaining Cohort, Time and Age Effects [PDF]
The relationship between home ownership of Dutch elderly households and age is strongly negative. Other studies suggest that this age gradient should be attributed to a cohort effect. In this paper we investigate where those cohort effects come from.
Anna van der Schors +2 more
core +3 more sources
Explaining black box decisions by Shapley cohort refinement [PDF]
arXiv, 2019 We introduce a variable importance measure to quantify the impact of individual input variables to a black box function. Our measure is based on the Shapley value from cooperative game theory. Many measures of variable importance operate by changing some predictor values with others held fixed, potentially creating unlikely or even logically impossible
arxiv