Results 191 to 200 of about 3,959,577 (361)

Cohort Profile: The Swiss HIV Cohort Study [PDF]

International Journal of Epidemiology, 2009
Swiss HIV Cohort Study,, Schoeni-Affolter, Franziska, Ledergerber, Bruno, Rickenbach, Martin, Rudin, Christoph, Günthard Huldrych, F., Telenti, Amalio, Furrer, Hansjakob, Yerly, Sabine, Francioli, Patrick   +9 more
openaire   +4 more sources

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Manifestations of cerebral dysfunction in infancy and their association with toxaemia and antepartum haemorrhage. A cohort study.

, 1971
C J Roberts
openalex   +1 more source

Retrospective cohort mortality study of workers at an aircraft maintenance facility. I. Epidemiological results. [PDF]

, 1991
Robert Spirtas, Patricia A. Stewart, J S Lee, Donald E. Marano, C D Forbes, D. Grauman, Hugh M. Pettigrew, A. Blair, Robert N. Hoover, J L Cohen   +9 more
openalex   +1 more source

Measuring the impact of Educational Interventions on the Academic Performance of Academic Development Students in Second-Year Microeconomics [PDF]

This paper analyses the impact of educational interventions made in the first- and second-year microeconomics courses on academic development students’ final mark in the second-year course.
Leonard Smith, Vimal Ranchhod
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Multiple sclerosis clinical decision support system based on projection to reference datasets

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1863-1873, December 2022., 2022
Abstract Objective Multiple sclerosis (MS) is a multifactorial disease with increasingly complicated management. Our objective is to use on‐demand computational power to address the challenges of dynamically managing MS. Methods A phase 3 clinical trial data (NCT00906399) were used to contextualize the medication efficacy of peg‐interferon beta‐1a vs ...
Chadia Ed‐driouch, Florent Chéneau, Françoise Simon, Guillaume Pasquier, Benoit Combès, Anne Kerbrat, Emmanuelle Le Page, Sophie Limou, Nicolas Vince, David‐Axel Laplaud, Franck Mars, Cédric Dumas, Gilles Edan, Pierre‐Antoine Gourraud   +13 more
wiley   +1 more source

Lipid profile in minor thalassemic patients: a historical cohort study

, 1970
M Hashemieh, Mohsen Javadzadeh, Afshan Shirkavand, Kourosh Sheibani   +3 more
openalex   +2 more sources

Tryptophan‐sensing receptor GPR142 expression levels are directly regulated by proinflammatory cytokines in ghrelin‐producing cells

FEBS Open Bio, EarlyView.
GPR142, a tryptophan‐sensing receptor, stimulates gastrointestinal hormones like ghrelin and is linked to inflammation regulation. Proinflammatory cytokines suppress ghrelin production, while tryptophan levels decrease via IDO1 activation. Our findings reveal that proinflammatory cytokines directly regulate GPR142 expression in ghrelin‐producing cells,
Yoko Ueda, Hiroshi Iwakura, Takuya Ensho, Mika Bando‐Shimizu, Asako Doi, Norihiko Matsutani, Shuhei Morita, Hidefumi Inaba, Hiroyuki Ariyasu, Naoki Fukuda, Keiji Hayata, Toshiyasu Ojima, Masahiro Nishi, Taka‐aki Matsuoka, Hiroki Yamaue, Takashi Akamizu   +15 more
wiley   +1 more source

Well‐being on supportive techniques in amyotrophic lateral sclerosis: from neurologists' perspective

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1874-1883, December 2022., 2022
Abstract Objective To investigate intercultural neurologists' perception of well‐being in patients with amyotrophic lateral sclerosis (ALS) using gastrostomy (PEG), non‐invasive, and/or invasive ventilation (NIV/IV) and to analyse the determinants and impact on the management of the above medical interventions (MIs).
Krzysztof Barć, Dorothée Lulé, Julia Finsel, Olga Helczyk, Susanne Baader, Helena Aho‐Özhan, Albert C. Ludolph, Magdalena Kuźma‐Kozakiewicz   +7 more
wiley   +1 more source