Results 61 to 70 of about 3,548,242 (334)

Prevalence of and factors associated with unplanned pregnancy among women in Koshu, Japan: cross-sectional evidence from Project Koshu, 2011–2016

BMC Pregnancy and Childbirth, 2020
Background Unplanned pregnancy is a public health issue with adverse consequences for maternal and neonatal health. In Japan, the prevalence of unplanned pregnancy was 46.2% in 2002.
Son Trung Huynh, Hiroshi Yokomichi, Yuka Akiyama, Reiji Kojima, Sayaka Horiuchi, Tadao Ooka, Ryoji Shinohara, Zentaro Yamagata   +7 more
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Descriptive epidemiology of muscle-strengthening activities in Japanese middle-aged and older adults: the Hisayama Study

BMJ Public Health
Introduction Data on the prevalence of muscle-strengthening activities in Asia have been limited. Using data from a community-based cross-sectional survey of a general adult population in Japan, whose age and occupational distribution were very similar ...
Jun Hata, Toshiharu Ninomiya, Takanari Kitazono, Takanori Honda, Mao Shibata, Satoko Sakata, Emi Oishi, Yoshihiko Furuta   +7 more
doaj   +1 more source

Attrition in a 30-year follow-up of a perinatal birth risk cohort: factors change with age [PDF]

PeerJ, 2014
Background. Attrition is a major cause of potential bias in longitudinal studies and clinical trials. Attrition rate above 20% raises concern of the reliability of the results.
Jyrki Launes, Laura Hokkanen, Marja Laasonen, Annamari Tuulio-Henriksson, Maarit Virta, Jari Lipsanen, Pentti J. Tienari, Katarina Michelsson   +7 more
doaj   +2 more sources

Health of Philippine Emigrants Study (HoPES): study design and rationale. [PDF]

, 2018
BackgroundImmigrants to the United States are usually healthier than their U.S.-born counterparts, yet the health of immigrants declines with duration of stay in the U.S.
Brindle, Eleanor, Crespi, Catherine M, de Castro, AB, Gee, Gilbert C, Hing, Anna K, Kabamalan, Maria Midea M, Lee, Nanette R, Llave, Karen, Wang, May C   +8 more
core   +1 more source

Cohort Profile: the Jerusalem longitudinal cohort study [PDF]

International Journal of Epidemiology, 2008
Whilst it has been suggested that about 25% of the variability in human longevity is attributed to genetic influences, the remaining 75% is consequent upon a complex interplay of biological, environmental, social and culturally determined factors. In rising to the challenge of understanding the complexities of human ageing, a valuable tool to emerge in
Eliana Ein-Mor, Jochanan Stessman, Michael Bursztyn, Daniel Azoulay, Jeremy M. Jacobs, Aaron Cohen   +5 more
openaire   +3 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Screening mammography performance according to breast density: a comparison between radiologists versus standalone intelligence detection

Breast Cancer Research
Background Artificial intelligence (AI) algorithms for the independent assessment of screening mammograms have not been well established in a large screening cohort of Asian women.
Mi-ri Kwon, Yoosoo Chang, Soo-Youn Ham, Yoosun Cho, Eun Young Kim, Jeonggyu Kang, Eun Kyung Park, Ki Hwan Kim, Minjeong Kim, Tae Soo Kim, Hyeonsoo Lee, Ria Kwon, Ga-Young Lim, Hye Rin Choi, JunHyeok Choi, Shin Ho Kook, Seungho Ryu   +16 more
doaj   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Comparative analysis of gut microbiota associated with body mass index in a large Korean cohort

BMC Microbiology, 2017
Background Gut microbiota plays an important role in the harvesting, storage, and expenditure of energy obtained from one’s diet. Our cross-sectional study aimed to identify differences in gut microbiota according to body mass index (BMI) in a Korean ...
Yeojun Yun, Han-Na Kim, Song E. Kim, Seong Gu Heo, Yoosoo Chang, Seungho Ryu, Hocheol Shin, Hyung-Lae Kim   +7 more
doaj   +1 more source