Results 61 to 70 of about 43,381,677 (339)

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Screening mammography performance according to breast density: a comparison between radiologists versus standalone intelligence detection

Breast Cancer Research
Background Artificial intelligence (AI) algorithms for the independent assessment of screening mammograms have not been well established in a large screening cohort of Asian women.
Mi-ri Kwon, Yoosoo Chang, Soo-Youn Ham, Yoosun Cho, Eun Young Kim, Jeonggyu Kang, Eun Kyung Park, Ki Hwan Kim, Minjeong Kim, Tae Soo Kim, Hyeonsoo Lee, Ria Kwon, Ga-Young Lim, Hye Rin Choi, JunHyeok Choi, Shin Ho Kook, Seungho Ryu   +16 more
doaj   +1 more source

Blood pressure, hypertension and the risk of abdominal aortic aneurysms: a systematic review and meta-analysis of cohort studies

European Journal of Epidemiology, 2019
Abdominal aortic aneurysms (AAA) are fatal in 80% of the cases when ruptured. Hypertension has been considered a potential risk factor for AAA; but the findings from prospective cohort studies have not been entirely consistent, nor have they been ...
Elsa Kobeissi, M. Hibino, H. Pan, D. Aune   +3 more
semanticscholar   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Cohort profile: The Kilombero and Ulanga Antiretroviral Cohort (KIULARCO)

Swiss Medical Weekly, 2017
BACKGROUND The Kilombero and Ulanga Antiretroviral Cohort (KIULARCO) is a single-site, open and ongoing prospective cohort of people living with human immunodeficiency virus (PLWHIV) established in 2005 at the Chronic Diseases Clinic of ...
Emilio Letang, Aneth Vedastus Kalinjuma, Tracy R Glass, Anna Gamell, Herry Mapesi, George Sikalengo, Lameck Bonaventure Luwanda, Dorcas Mnzava, Alex J Ntamatungiro, Regina Ndaki, Gideon Francis, Fiona Vanobberghen, Hansjakob Furrer, Thomas Klimkait, Ingrid Felger, Marcel Tanner, Christoph Hatz, Maja Weisser, Manuel Battegay, on behalf of the KIULARCO Study Group   +19 more
doaj   +1 more source

Relative validity of a food frequency questionnaire for adolescents from a capital in the Northeastern region of Brazil [PDF]

Brazilian Journal of Medical and Biological Research, 2020
The present study was conducted to evaluate the validity of the Food Frequency Questionnaire (FFQ) used in the RPS Birth Cohort Consortium (Ribeirão Preto, Pelotas, and São Luís) to assess dietary intake of adolescents from São Luís, Maranhão.
E.G. Bogea, A.K.T.C. França, M.L.B.M. Bragança, J.S. Vaz, M.C. Assunção, M.A. Barbieri, H. Bettiol, A.A.M. Silva   +7 more
doaj   +1 more source

Congenital Heart Disease and Risk of Cardiovascular Disease: A Meta‐Analysis of Cohort Studies

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2019
Background Despite remarkable success in the surgical and medical management of congenital heart disease (CHD), some survivors still experience cardiovascular complications over the long term.
Tingting Wang, Lizhang Chen, Tubao Yang, Peng Huang, Lesan Wang, Li-juan Zhao, Senmao Zhang, Ziwei Ye, Letao Chen, Zan Zheng, J. Qin   +10 more
semanticscholar   +1 more source

Cohort Profile: the Jerusalem longitudinal cohort study [PDF]

International Journal of Epidemiology, 2008
Whilst it has been suggested that about 25% of the variability in human longevity is attributed to genetic influences, the remaining 75% is consequent upon a complex interplay of biological, environmental, social and culturally determined factors. In rising to the challenge of understanding the complexities of human ageing, a valuable tool to emerge in
Eliana Ein-Mor, Jochanan Stessman, Michael Bursztyn, Daniel Azoulay, Jeremy M. Jacobs, Aaron Cohen   +5 more
openaire   +3 more sources

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Comparative analysis of gut microbiota associated with body mass index in a large Korean cohort

BMC Microbiology, 2017
Background Gut microbiota plays an important role in the harvesting, storage, and expenditure of energy obtained from one’s diet. Our cross-sectional study aimed to identify differences in gut microbiota according to body mass index (BMI) in a Korean ...
Yeojun Yun, Han-Na Kim, Song E. Kim, Seong Gu Heo, Yoosoo Chang, Seungho Ryu, Hocheol Shin, Hyung-Lae Kim   +7 more
doaj   +1 more source