Results 81 to 90 of about 43,381,677 (339)

Fruit and vegetable consumption and mortality from all causes, cardiovascular disease, and cancer: systematic review and dose-response meta-analysis of prospective cohort studies

open access: yesBritish medical journal, 2014
Objective To examine and quantify the potential dose-response relation between fruit and vegetable consumption and risk of all cause, cardiovascular, and cancer mortality.
Xia Wang   +6 more
semanticscholar   +1 more source

Representativeness of the LifeLines Cohort Study

open access: yesPLOS ONE, 2015
LifeLines is a large prospective population-based three generation cohort study in the north of the Netherlands. Different recruitment strategies were adopted: recruitment of an index population via general practitioners, subsequent inclusion of their family members, and online self-registration. Our aim was to investigate the representativeness of the
Klijs, B.   +5 more
openaire   +6 more sources

Cohort Profile Update: The GAZEL Cohort Study [PDF]

open access: yesInternational Journal of Epidemiology, 2014
The original GAZEL cohort was composed of 20 625 employees of the French national gas and electricity companies (15 011 male employees then aged 40 to 50 years and 5614 women between 35 and 50 years old) at its inception in 1989. A Cohort Profile article was published in 2007.
Marcel Goldberg   +2 more
openaire   +3 more sources

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

The Relationship between Vegetable Intake and Weight Outcomes: A Systematic Review of Cohort Studies

open access: yesNutrients, 2018
The relationship between vegetable consumption and measures of adiposity was assessed in cohort studies. Seven databases were searched from inception until October 2018.
M. Nour   +3 more
semanticscholar   +1 more source

Cohort Studies [PDF]

open access: yesClinical Journal of the American Society of Nephrology, 2006
Because of their well-documented advantages, randomized controlled trials (RCTs) represent the gold standard for testing hypotheses in medical research. However, RCTs are not ideal for addressing certain research questions ( e.g. , the risk for renal insufficiency associated with alcohol intake).
Marcello Tonelli, Ravi Thadhani
openaire   +3 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

The Hertfordshire Cohort Study: an overview [PDF]

open access: yesF1000Research, 2019
The Hertfordshire Cohort Study is a nationally unique study of men and women born in the English county of Hertfordshire in the early part of the 20th century. Records that detail their health in infancy and childhood have been preserved, their sociodemographic, lifestyle, medical and biological attributes have been characterised in later life, and ...
Cyrus Cooper   +6 more
openaire   +4 more sources

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

Sex Differences in Birth Weight and Physical Activity in Japanese Schoolchildren

open access: yesJournal of Epidemiology, 2018
Background: Lower birth weight (BW) is associated with increased chronic disease risk later in life. Previous studies suggest that this may be mediated principally via physical activity (PA). However, the association between BW and PA in children has not
Mitsuya Yamakita   +4 more
doaj   +1 more source

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