Results 81 to 90 of about 3,374,176 (336)

Representativeness of the LifeLines Cohort Study

PLOS ONE, 2015
LifeLines is a large prospective population-based three generation cohort study in the north of the Netherlands. Different recruitment strategies were adopted: recruitment of an index population via general practitioners, subsequent inclusion of their family members, and online self-registration. Our aim was to investigate the representativeness of the
Klijs, B., Scholtens, S., Mandemakers, J.J., Snieder, H., Stolk, R.P., Smidt, N.   +5 more
openaire   +6 more sources

Cohort Profile Update: The GAZEL Cohort Study [PDF]

International Journal of Epidemiology, 2014
The original GAZEL cohort was composed of 20 625 employees of the French national gas and electricity companies (15 011 male employees then aged 40 to 50 years and 5614 women between 35 and 50 years old) at its inception in 1989. A Cohort Profile article was published in 2007.
Marcel Goldberg, Marie Zins, Annette Leclerc   +2 more
openaire   +3 more sources

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Risk of selection bias due to non-participation in a cohort study on pubertal timing. [PDF]

, 2020
BackgroundNon-participation in aetiologic studies of pubertal timing is frequent. However, little effort has been given to explore the risk and potential impact of selection bias in studies of pubertal timing.ObjectiveWe aimed to explore the risk of ...
Arah, Onyebuchi A, Brix, Nis, Ernst, Andreas, Henriksen, Tine Brink, Lauridsen, Lea Lykke Braskhøj, Olsen, Jørn, Parner, Erik Thorlund, Ramlau-Hansen, Cecilia Høst   +7 more
core  

Dairy consumption and cardiometabolic diseases: systematic review and updated meta-analyses of prospective cohort studies [PDF]

, 2018
Purpose of Review Dairy products contain both beneficial and harmful nutrients in relation to cardiometabolic diseases. Here, we provide the latest scientific evidence regarding the relationship between dairy products and cardiometabolic diseases by ...
A Hruby, A Lamri, A Tremblay, A Tremblay, AG Pittas, B Haring, B Lamarche, BJ Fuhrman, D Aune, D Gao, D Hu, D Kromhout, D Mozaffarian, D Mozaffarian, Daniel Lisko, DD Alexander, DI Givens, Doreen Gille, E Yu, EM Brouwer-Brolsma, F Rosqvist, FP Hartwig, G Buckland, GC Chen, Global Burden of Disease Risk Factors Collaborators, Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration, GW Dalmeijer, HEK Virtanen, HK Bergholdt, HK Bergholdt, HK Choi, I Sluijs, J Bodner-Montville, J Goede de, J Praagman, J Praagman, JA Nettleton, Jing Guo, JJ Dinicolantonio, JM Geleijnse, JP Drouin-Chartier, JP Drouin-Chartier, JP Higgins, JR Benatar, K Ge, KM Turner, L Brink, L Gijsbers, L Pimpin, L Schwingshackl, LA Mierlo van, LET Vissers, LM O'Connor, LQ Qin, M Chen, M Ding, M Kratz, M Talaei, M Talaei, M Talaei, M Talaei, MA Aerde van, MC Oliveira Otto de, ME Labonte, Mendelian Randomization of Dairy Consumption Working Group, MU Jakobsen, N Moslehi, NM Grantham, P Elwood, PC Elwood, Q Liu, Q Yang, R Villegas, S Greenland, S Parvez, Shuang Tian, SR Bauer, SS Lim, SS Soedamah-Muthu, SS Soedamah-Muthu, U Ericson, V Dilis, X Tong   +82 more
core   +3 more sources

Cohort Studies [PDF]

Clinical Journal of the American Society of Nephrology, 2006
Because of their well-documented advantages, randomized controlled trials (RCTs) represent the gold standard for testing hypotheses in medical research. However, RCTs are not ideal for addressing certain research questions ( e.g. , the risk for renal insufficiency associated with alcohol intake).
Marcello Tonelli, Ravi Thadhani
openaire   +3 more sources

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Treatment for congenital toxoplasmosis: finding out what works [PDF]

, 2009
Evidence for the effectiveness of prenatal or postnatal treatment for congenital toxoplasmosis will be critical to guide policy about prenatal and neonatal screening over the next 10 years, let alone the next 100.
Gilbert, R
core   +3 more sources

The Hertfordshire Cohort Study: an overview [PDF]

F1000Research, 2019
The Hertfordshire Cohort Study is a nationally unique study of men and women born in the English county of Hertfordshire in the early part of the 20th century. Records that detail their health in infancy and childhood have been preserved, their sociodemographic, lifestyle, medical and biological attributes have been characterised in later life, and ...
Cyrus Cooper, Cyrus Cooper, Sian M. Robinson, S. J. Simmonds, Sarah Carter, Elaine M. Dennison, Holly E. Syddall   +6 more
openaire   +4 more sources

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source