Results 101 to 110 of about 2,873,998 (272)

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Increasing hepatitis C virus RNA levels in hemophiliacs: relationship to human immunodeficiency virus infection and liver disease. Multicenter Hemophilia Cohort Study [PDF]

, 1994
M. Elaine Eyster, MW Fried, AM Di Bisceglie, J. J. Goedert   +3 more
openalex   +3 more sources

Explaining black box decisions by Shapley cohort refinement [PDF]

arXiv, 2019
We introduce a variable importance measure to quantify the impact of individual input variables to a black box function. Our measure is based on the Shapley value from cooperative game theory. Many measures of variable importance operate by changing some predictor values with others held fixed, potentially creating unlikely or even logically impossible
arxiv  

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Prospective study of diarrhoeal disease in a cohort of rural Mexican children: incidence and isolated pathogens during the first two years of life [PDF]

, 1988
Alejandro Cravioto, Rosa Reyes, Roberto Ortega, G. Esteban Fernández, Raymundo Hernández, Dolores López   +5 more
openalex   +1 more source

Impact of closed-off management due to COVID-19 rebound on maternal depression during pregnancy

BMC Pregnancy and Childbirth
Background This study aimed to assess the impacts of closed-off measures with different strictness levels (lockdown, partial lockdown and non-lockdown) and geographic proximity to patients with coronavirus disease 2019 (COVID-19) on prenatal depression ...
Wanqing Xiao, Yuting Yang, Huiyun Xiao, Peiyuan Huang, Dongmei Wei, Yingfang Wu, Jia Yu, Jian-Rong He, Xiu Qiu   +8 more
doaj   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Pelvic inflammatory disease and the intrauterine device: findings in a large cohort study. [PDF]

, 1981
Martin Vessey, D Yeates, Rosemary Flavel, Klim McPherson   +3 more
openalex   +1 more source

Association of maternal blood mercury concentration during the first trimester of pregnancy with birth outcomes

Scientific Reports
Exposure to mercury has been associated with adverse effects on pregnancy outcomes. However, there is limited literature on mercury exposure and pregnancy outcomes in Chinese pregnant women.
Wei Li, Chong Miao, Bin Sun, Zhengqin Wu, Xinrui Wang, Haibo Li, Haiyan Gao, Yibing Zhu, Hua Cao   +8 more
doaj   +1 more source

Distinct lung function and bronchodilator responses between term and preterm young children with recurrent wheezing

Pediatrics and Neonatology, 2021
Background: Recurrent or unresolved wheezing is a common complaint in certain young children populations, especially those born preterm. Using infant lung function testing, we aimed to distinguish the differences between term and preterm young children ...
Shen-Hao Lai, Ming-Han Tsai, Man-Chin Hua, Kuo-Wei Yeh, Tsung-Chieh Yao, Jing-Long Huang, Sui-Ling Liao   +6 more
doaj