Results 111 to 120 of about 2,917,326 (313)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Prevalence and risk factors for venous thromboembolic complications in the Swiss Inflammatory Bowel Disease Cohort.

, 2016
OBJECTIVE Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is associated with the occurrence of venous thromboembolism (VTE) such as deep vein thrombosis (DVT) and pulmonary embolism (PE).
Safroneeva, Ekaterina, Engelberger, R.P., Safroneeva, E., Biedermann, L., Alatri, Adriano, Vavricka, Stephan, Mazzolai, Lucia, Calanca, L., Fournier, N., Vavricka, S., Calanca, Luca, Engelberger, Rolf Peter, Fournier, Nicolas, Schoepfer, A., Mazzolai, L., Alatri, A., Schoepfer, Alain, Swiss IBD Cohort Study Group, Biedermann, Luc   +18 more
core   +1 more source

Child inhibitory control in toddlerhood: associations with child interaction skills with the mother

BMC Psychology
Childhood inhibitory control (IC) is a key precursor of later social development, yet the mechanisms through which IC contributes to emerging interaction skills in toddlerhood remain insufficiently understood. We explored the cross-sectional associations
Pauliina Juntunen, Riikka Korja, Jetro J. Tuulari, Eeva Eskola, Eeva Holmberg, Anniina Karonen, Marika Otranen, Elmo P. Pulli, Eeva-Leena Kataja, David J. Bridgett, Hasse Karlsson, Linnea Karlsson, Saara Nolvi   +12 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The FinnBrain multimodal neonatal template and atlas collection

Communications Biology
The accurate processing of neonatal and infant brain MRI data is crucial for developmental neuroscience but presents unique challenges that child and adult data do not.
Jetro J. Tuulari, Aylin Rosberg, Elmo P. Pulli, Niloofar Hashempour, Elena Ukharova, Kristian Lidauer, Ashmeet Jolly, Silja Luotonen, Hilyatushalihah K. Audah, Elena Vartiainen, Wajiha Bano, Ilkka Suuronen, Isabella L. C. Mariani Wigley, Vladimir S. Fonov, D. Louis Collins, Harri Merisaari, Linnea Karlsson, Hasse Karlsson, John D. Lewis   +18 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Impact of screening and antiretroviral therapy on anal cancer incidence in HIV-positive MSM [PDF]

, 2017
BACKGROUND The incidence of anal cancer is high in HIV-positive men who have sex with men (MSM). We modeled the impact of screening strategies and combination antiretroviral therapy (cART) coverage on anal cancer incidence in Switzerland. METHODS
Olivia Keiser, Egger, Matthias, Calmy, A., Keiser, O., Roger D. Kouyos, Kouyos, Roger D., Estill, J., Kouyos, RD, Cavassini, M., Estill, J, Blaser, N, Cavassini, M, Heiner C. Bucher, Blaser, Nello, Bertisch, B., Calmy, Alexandra, Bucher, Heiner C, Bertisch, B, Blaser, N., Calmy, A, Egger, M, Swiss HIV Cohort Study, Barbara Bertisch, Estill, Janne Anton Markus, Matthias Egger, Keiser, Olivia, Bertisch, Barbara, Kouyos, Roger D, Egger, M., Alexandra Calmy, Janne Estill, Kouyos, R.D., Nello Blaser, Swiss HIV Cohort, Study, Bucher, HC, Bucher, Heiner C., Study, The Swiss HIV Cohort, Bucher, H.C., Keiser, O, Cavassini, Matthias, Estill, Janne, Matthias Cavassini   +41 more
core   +1 more source

Cohort Profile: The Doetinchem Cohort Study [PDF]

International Journal of Epidemiology, 2008
Verschuren, WMMrivm, Blokstra, A, Picavet, HSJrivm, Smit, HArivm   +3 more
openaire   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source