Results 101 to 110 of about 32,535,913 (263)

Maternal Pregnancy-Related Anxiety Is Associated With Sexually Dimorphic Alterations in Amygdala Volume in 4-Year-Old Children

Frontiers in Behavioral Neuroscience, 2019
Prenatal stress is associated with child behavioral outcomes increasing susceptibility for psychiatric disorders in later life. Altered fetal brain development might partly mediate this association, as some studies suggest.
Henriette Acosta, Jetro J. Tuulari, Jetro J. Tuulari, Jetro J. Tuulari, Noora M. Scheinin, Niloofar Hashempour, Olli Rajasilta, Tuomas I. Lavonius, Juho Pelto, Virva Saunavaara, Riitta Parkkola, Tuire Lähdesmäki, Linnea Karlsson, Linnea Karlsson, Hasse Karlsson, Hasse Karlsson   +15 more
doaj   +1 more source

Factors influencing treatment status of syphilis among pregnant women: a retrospective cohort study in Guangzhou, China

International Journal for Equity in Health, 2023
Background Many syphilis infected pregnant women do not receive treatment, representing a major missed opportunity to reduce the risk of syphilis-related adverse pregnancy outcomes.
Huihui Liu, Niannian Chen, Weiming Tang, Songying Shen, Jia Yu, Huiyun Xiao, Xingwen Zou, Jianrong He, Joseph D. Tucker, Xiu Qiu   +9 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Prevalence of vascular disease in systemic lupus erythematosus compared with type-1 diabetes mellitus: a cross-sectional study of two cohorts. [PDF]

, 2015
OBJECTIVES Systemic lupus erythematosus (SLE) is associated with considerable cardiovascular morbidity that has not yet been directly compared with other diseases with known cardiovascular risk.
Ribi, Camillo, Zulewski, H, Koenig, K.F., Radosavac, M, Koenig, K. F., Zulewski, H., Trendelenburg, M., Ribi, C, Huynh-Do, Uyen, Koenig, K F, Radosavac, M., Trendelenburg, Marten, Ribi, C., Swiss, S. L. E. cohort study, Swiss SLE cohort study (SSCS), Trendelenburg, M   +15 more
core   +1 more source

The Millennium Cohort Study.

Population trends, 2002
The Millennium Cohort Study is the latest in the line of British birth cohort studies. MCS resembles its predecessors which follow people born in 1946, 1958 and 1970 in the intention to become multi-purpose longitudinal data resource charting many aspects of individual's lives over time.
Smith, K, Joshi, H
openaire   +2 more sources

A cohort profile of the Graham Roberts study cohort

Frontiers in Oncology
PurposeThe Graham Roberts Study was initiated in 2018 and is the first Trials Within Cohorts (TwiCs) study for bladder cancer. Its purpose is to provide an infrastructure for answering a breadth of research questions, including clinical, mechanistic, and supportive care centred questions for bladder cancer patients.ParticipantsAll consented patients ...
Russell, Beth, Leech, Poppy, Wylie, Harriet, Moss, Charlotte, Haire, Anna, Enting, Deborah, Amery, Suzanne, Chatterton, Kathryn, Khan, Muhammad Shamin, Thurairaja, Ramesh, Nair, Rajesh, Malde, Sachin, Smith, Kate, Gillett, Cheryl, Josephs, Debra, Pintus, Elias, Rudman, Sarah, Hughes, Simon, Relton, Clare, Van Hemelrijck, Mieke   +19 more
openaire   +4 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source