Results 131 to 140 of about 2,917,326 (313)

Widely differing screening and treatment practice for osteoporosis in patients with inflammatory bowel diseases in the Swiss IBD cohort study [PDF]

, 2017
Low bone mineral density (BMD) and osteoporosis remain frequent problems in patients with inflammatory bowel diseases (IBDs). Several guidelines with nonidentical recommendations exist and there is no general agreement regarding the optimal approach for ...
Rogler, Gerhard, Thomas Greuter, Greuter, T., Greuter, Thomas, Rogler, G., Zeitz, J., Freitas-Queiroz, Natália, Luc Biedermann, Frey, D., Rossel, Jean-Benoît, Benjamin Misselwitz, Vavricka, S.R., Scharl, M., Kuntzen, T., Stephan R. Vavricka, Rossel, J.B., Misselwitz, B., Swiss IBD Cohort Study Group, Natália Freitas-Queiroz, Biedermann, Luc, Misselwitz, Benjamin, Biedermann, L., Kuntzen, Thomas, Freitas-Queiroz, N., Jonas Zeitz, Thomas Kuntzen, Diana Frey, Schüle, Solvey, Gerhard Rogler, Scharl, Michael, Zeitz, Jonas, Michael Scharl, Solvey Schüle, Jean-Benoît Rossel, Frey, Diana, Vavricka, Stephan R, Schüle, S.   +36 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Maternal employment and early childhood overweight: findings from the UK Millennium Cohort Study

, 2008
Background: In most developed countries, maternal employment has increased rapidly. Changing patterns of family life have been suggested to be contributing to the rising prevalence of childhood obesity.
Law, C., Hawkins, S.S., Millennium Cohort Study Child Health Group, The, Cole, T.J.   +3 more
core  

The appearance of joint manifestations in the Swiss inflammatory bowel disease cohort. [PDF]

, 2019
Background/aimsExtraintestinal manifestations (EIM) involving joints, skin, eyes and liver represent an important problem in the treatment of IBD patients. The aim of this study was to identify factors that are associated with the occurrence of joint EIM
Rogler, Gerhard, Hiller, A., Nicolas Fournier, Rogler, G., Ciurea, Adrian, Butter, M., Luc Biedermann, Scharl, Michael; https://orcid.org/, Vavricka, S.R., Scharl, M., Swiss IBD Cohort Study Group, Biedermann, Luc, Stephan R Vavricka, Biedermann, L., Butter, Matthias, Hiller, Aimee, Matthias Butter, Fournier, N., Aimee Hiller, Gerhard Rogler, Fournier, Nicolas, Adrian Ciurea, Michael Scharl, Vavricka, Stephan R, Ciurea, A.   +24 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Choice of initial combination antiretroviral therapy in individuals with hiv infection: determinants and outcomes

, 2012
BACKGROUND: Current guidelines give recommendations for preferred combination antiretroviral therapy (cART). We investigated factors influencing the choice of initial cART in clinical practice and its outcome.
Battegay, Manuel, Erb, Stefan, Furrer, Hansjakob; https://orcid.org/, Cavassini, M., Bernasconi, Enos; https://orcid.org/, Swiss HIV Cohort Study,, Elzi, L., Vernazza, P., Battegay, M., Ledergerber, B., Ledergerber, Bruno; https://orcid.org/, Battegay, Manuel; https://orcid.org/, Bernasconi, Enos, Weber, R., Elzi, Luigia; https://orcid.org/, Furrer, Hansjakob, Hirschel, Bernard, Furrer, H., Weber, Rainer; https://orcid.org/, Erb, S., Ledergerber, Bruno, Cavassini, Matthias; https://orcid.org/, Elzi, Luigia, Vernazza, Pietro, Weber, Rainer, Hirschel, B., Vernazza, Pietro; https://orcid.org/, Cavassini, Matthias, Bernasconi, E.   +28 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source