Results 141 to 150 of about 4,513,718 (313)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Determining factors in relation to lymphovascular characteristics and anastomotic configuration in supermicrosurgical lymphaticovenous anastomosis – A retrospective cohort study

, 2020
Po-Lun Tsai, Shao‐Chun Wu, Wei‐Che Lin, Daisuke Mito, Min‐Hsien Chiang, Ching‐Hua Hsieh, Johnson Chia‐Shen Yang   +6 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Effect of previous placenta previa on outcome of next pregnancy: a 10-year retrospective cohort study [PDF]

, 2020
Lizi Zhang, Shilei Bi, Lili Du, Jingjin Gong, Jingsi Chen, Wen Sun, Xinyang Shen, Jingman Tang, Luwen Ren, Guolu Chai, Zhijian Wang, Dunjin Chen   +11 more
openalex   +1 more source

Dupilumab treatment for atopic dermatitis is associated with decreased utilization of psychostimulants for attention deficit hyperactivity disorder: A retrospective cohort study [PDF]

, 2023
Ahmet M. Yildirim, Taniya Pradhan, Zachary Zinn   +2 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The value of fetal growth trajectory during pregnancy in predicting small for gestational age neonates at term

BMC Pregnancy and Childbirth
Background The predictive value of trajectory identified by group-based trajectory modeling (GBTM) has been discussed but its value in predicting small for gestational age (SGA) neonates is still unclear.
Huimin Zhu, Min Wei, Xiuxiu Li, Xuemei Liu, Jin Li, Xuemei Fan, Zhen Wang, Weiqing Chen   +7 more
doaj   +1 more source

Factors associated with COVID-19 vaccine uptake in people with kidney disease: an OpenSAFELY cohort study [PDF]

, 2023
Edward P K Parker, John Tazare, William Hulme, Christopher Bates, Edward J Carr, Jonathan Cockburn, Helen J Curtis, Louis Fisher, Amelia Green, Sam Harper, Frank Hester, Elsie Horne, Fiona Loud, Susan Lyon, Viyaasan Mahalingasivam, Amir Mehrkar, Linda Nab, John Parry, Shalini Santhakumaran, Retha Steenkamp, Jonathan A C Sterne, Alex J Walker, Elizabeth Williamson, Michelle Willicombe, Bang Zheng, Ben Goldacre, Dorothea Nitsch, Laurie A. Tomlinson, Laurie A Tomlinson   +28 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source