Results 141 to 150 of about 43,437,062 (345)

Impact of closed-off management due to COVID-19 rebound on maternal depression during pregnancy

open access: yesBMC Pregnancy and Childbirth
Background This study aimed to assess the impacts of closed-off measures with different strictness levels (lockdown, partial lockdown and non-lockdown) and geographic proximity to patients with coronavirus disease 2019 (COVID-19) on prenatal depression ...
Wanqing Xiao   +8 more
doaj   +1 more source

Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study

open access: yesThe Lancet, 2020
N. Kuderer   +239 more
semanticscholar   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Association of maternal blood mercury concentration during the first trimester of pregnancy with birth outcomes

open access: yesScientific Reports
Exposure to mercury has been associated with adverse effects on pregnancy outcomes. However, there is limited literature on mercury exposure and pregnancy outcomes in Chinese pregnant women.
Wei Li   +8 more
doaj   +1 more source

Distinct lung function and bronchodilator responses between term and preterm young children with recurrent wheezing

open access: yesPediatrics and Neonatology, 2021
Background: Recurrent or unresolved wheezing is a common complaint in certain young children populations, especially those born preterm. Using infant lung function testing, we aimed to distinguish the differences between term and preterm young children ...
Shen-Hao Lai   +6 more
doaj  

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald   +18 more
wiley   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias   +12 more
wiley   +1 more source

Long‐term effect of caesarean section on the gut microbial taxonomical profile and metabolic function of children at pre‐school age

open access: yesClinical and Translational Medicine, 2023
Chang Gao   +7 more
doaj   +1 more source

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