Results 141 to 150 of about 43,437,062 (345)
Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study
The Lancet, 2020 N. Kuderer, T. Choueiri, D. Shah, Y. Shyr, S. Rubinstein, D. Rivera, S. Shete, Chih-Yuan Hsu, A. Desai, Gilberto Lopes, P. Grivas, P. Grivas, C. Painter, S. Peters, M. Thompson, Z. Bakouny, G. Batist, T. Bekaii-Saab, M. Bilen, N. Bouganim, M. B. Larroya, D. Castellano, S. Prete, D. Doroshow, P. Egan, A. Elkrief, D. Farmakiotis, D. Flora, M. Galsky, M. Glover, E. Griffiths, A. Gulati, Shilpa Gupta, Navid Hafez, T. Halfdanarson, J. Hawley, E. Hsu, A. Kasi, A. Khaki, A. Khaki, Christopher A. Lemmon, C. Lewis, Barbara B. Logan, T. Masters, R. McKay, R. Mesa, A. Morgans, M. Mulcahy, O. Panagiotou, P. Peddi, N. Pennell, K. Reynolds, Lane R. Rosen, R. Rosovsky, M. Salazar, A. Schmidt, Sumit A Shah, J. Shaya, J. Steinharter, K. Stockerl-Goldstein, S. Subbiah, D. Vinh, F. Wehbe, L. Weissmann, J. Wu, E. Wulff-Burchfield, Zhuoer Xie, Albert C. Yeh, Albert C. Yeh, P. Yu, A. Zhou, L. Zubiri, S. Mishra, G. Lyman, G. Lyman, B. Rini, J. Warner, M. Abidi, J. Acoba, Neeraj Agarwal, S. A. Ahmad, Archana Ajmera, Jessica Altman, Anne H. Angevine, Nilo Azad, Michael H. Bar, Aditya Bardia, Jill S. Barnholtz-Sloan, Briana Barrow, B. Bashir, Rimma Belenkaya, S. Berg, E. Bernicker, C. Bestvina, R. Bishnoi, Genevieve Marie Boland, Mark Bonnen, G. Bouchard, Daniel W. Bowles, F. Busser, A. Cabal, P. Caimi, Theresa M. Carducci, C. Casulo, James L. Chen, J. Clement, D. Chism, Erin Cook, C. Curran, Ahmad Daher, Mark Dailey, S. Dahiya, John Deeken, G. Demetri, Sandy DiLullo, N. Duma, Rawad Elias, B. Faller, L. Fecher, Lawrence E. Feldman, C. Friese, Paul Fu, Julie Fu, A. Futreal, J. Gainor, Jorge E Garcia, David M. Gill, E. Gillaspie, Antonio Giordano, Grace Glace, Axel Grothey, S. Gulati, M. Gurley, B. Halmos, Roy S. Herbst, D. Hershman, Kent Hoskins, R. Jain, Salma K. Jabbour, Alokkumar Jha, Douglas B. Johnson, Monika Joshi, K. Kelleher, J. Kharofa, H. Khan, J. Knoble, V. Koshkin, Amit A. Kulkarni, P. Lammers, J. Leighton, Mark A. Lewis, Xuanyi Li, Ang Li, K. M. Lo, A. Loaiza-Bonilla, Patricia LoRusso, C. Low, M. Lustberg, D. Mahadevan, Abdul-Hai Mansoor, Michelle Marcum, M. Markham, C. Marshall, Sandeep H. Mashru, Sara Matar, C. McNair, Shannon K. McWeeney, J. Mehnert, A. Menendez, H. Menon, M. Messmer, Ryan S. Monahan, Sarah Mushtaq, G. Nagaraj, Sarah Nagle, J. Naidoo, John M. Nakayama, Vikram M. Narayan, Heather H. Nelson, Eneida R. Nemecek, R. Nguyen, P. Nuzzo, P. Oberstein, A. Olszewski, Susie Owenby, M. Pasquinelli, John Philip, Sabitha Prabhakaran, M. Puc, Amelie G. Ramírez, J. Rathmann, S. Revankar, Young Soo Rho, Terence D. Rhodes, Robert L. Rice, Gregory Riely, J. Riess, Cameron Rink, E. Robilotti, Lori J. Rosenstein, B. Routy, M. Rovito, M. W. Saif, Amit Sanyal, L. Schapira, C. Schwartz, Oscar K. Serrano, Mansi Shah, Chintan Shah, Grace Shaw, A. Shergill, Geoffrey P. Shouse, Heloisa P. Soares, Carmen C. Solorzano, Pramod K. Srivastava, Karen Stauffer, D. Stover, Jamie Stratton, Catherine Stratton, V. Subbiah, R. Tamimi, N. Tannir, U. Topaloglu, E. V. Allen, S. V. Loon, Karen Vega-Luna, N. Venepalli, Amit Verma, Praveen Vikas, Sarah Wall, P. L. Weinstein, Matthias Weiss, T. Wise-Draper, William A. Wood, Wenxin Xu, S. Yackzan, R. Zacks, Tian Zhang, Andrea J. Zimmer, Jack West +239 moresemanticscholar +1 more sourceA nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun +13 morewiley +1 more sourceTherapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim +18 morewiley +1 more sourceUnraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández +12 morewiley +1 more source