Results 161 to 170 of about 45,688,233 (408)

A cohort profile of the Graham Roberts study cohort

Frontiers in Oncology
PurposeThe Graham Roberts Study was initiated in 2018 and is the first Trials Within Cohorts (TwiCs) study for bladder cancer. Its purpose is to provide an infrastructure for answering a breadth of research questions, including clinical, mechanistic, and supportive care centred questions for bladder cancer patients.ParticipantsAll consented patients ...
Beth Russell, Poppy Leech, Harriet Wylie, Charlotte Louise Moss, Anna Haire, Deborah Enting, Suzanne Amery, Kathryn Chatterton, Muhammad Shamim Khan, Ramesh Thurairaja, Rajesh Nair, Sachin Malde, Kate Smith, Cheryl Gillett, Debra Josephs, Elias Pintus, Sarah Rudman, Simon Hughes, Clare Relton, Mieke Van Hemelrijck   +19 more
openaire   +3 more sources

Cohort Profile Update: The Norwegian Mother and Child Cohort Study (MoBa).

International Journal of Epidemiology, 2016
This is an update of the Norwegian Mother and Child Cohort Study (MoBa) cohort profile which was published in 2006. Pregnant women attending a routine ultrasound examination were initially invited. The first child was born in October 1999 and the last in
P. Magnus, Charlotte Birke, Kristine Vejrup, A. Haugan, Elin R. Alsaker, A. Daltveit, M. Handal, M. Haugen, G. Høiseth, G. Knudsen, L. Paltiel, P. Schreuder, K. Tambs, L. Vold, C. Stoltenberg   +14 more
semanticscholar   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

GROWING UP IN IRELAND. Cohort '08 (Infant Cohort). Design, Instrumentation and Procedures for Cohort ’08 of Growing Up in Ireland at 9 Years Old (Wave 5) [PDF]

, 2019
Growing Up in Ireland is the national longitudinal cohort study of children that commenced in 2006. The study has followed two groups of Irish children: Cohort ’98 (so-called because most of them were born in 1998; formerly called the ‘Child Cohort ...
McNamara, Eoin, Murray, Aisling, O'Mahony, Desmond   +2 more
core  

Dynamics of affect modulation in neurodevelopmental disorders (DynAMoND) – study design of a prospective cohort study [PDF]

Attention-deficit-hyperactivity disorder; Bipolar disorder; Emotion dysregulationTrastorn per dèficit d'atenció i hiperactivitat; Trastorn bipolar; Desregulació emocionalTrastorno por déficit de atención e hiperactividad; Trastorno bipolar; Desregulación
Bayas, Maximilian, de Girolamo, Giovanni, Fadeuilhe, Christian, Kockler, Tobias Dominik, Munoz Caller, Silvia, Ramos-Quiroga, Josep Antoni   +5 more
core   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Effect of maternal age on the risk of preterm birth: A large cohort study

PLoS ONE, 2018
Background Maternal age at pregnancy is increasing worldwide as well as preterm birth. However, the association between prematurity and advanced maternal age remains controversial.
F. Fuchs, B. Monet, T. Ducruet, N. Chaillet, F. Audibert   +4 more
semanticscholar   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Antibiotherapy with and without bone debridement in diabetic foot osteomyelitis: a retrospective cohort study [PDF]

, 1969
Asım Ülçay, Ahmet Karakaş, Mesut Mutluoğlu, Günalp Uzun, Vedat Turhan, Hakan Ay   +5 more
openalex   +1 more source

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

The Lancet, 2020
F. Zhou, Ting Yu, R. Du, Guohui Fan, Y. Liu, Zhibo Liu, J. Xiang, Ye-ming Wang, Bin Song, Xiaoying Gu, Lulu Guan, Yuan Wei, Hui Li, Xudong Wu, Jiuyang Xu, Shengjin Tu, Yi Zhang, Hua Chen, B. Cao   +18 more
semanticscholar   +1 more source