Results 61 to 70 of about 43,437,062 (345)

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Hair Cortisol Concentrations Are Associated with Dental Anxiety during Pregnancy

Dentistry Journal, 2021
Dental anxiety (DA) and hair cortisol concentrations (HCC) are associated with psychological symptoms and vary during pregnancy. We aimed to examine the association between HCC and DA at two points of pregnancy.
Hilja Viitaniemi, Auli Suominen, Linnea Karlsson, Paula Mustonen, Susanna Kortesluoma, Kari Rantavuori, Ana João Rodrigues, Bárbara Coimbra, Hasse Karlsson, Satu Lahti   +9 more
doaj   +1 more source

Korean frailty and aging cohort study (KFACS): cohort profile

BMJ Open, 2020
Purpose The purpose of the Korean Frailty and Aging Cohort Study (KFACS) is to initiate a nationwide, population-based prospective cohort study of older adults living in the community to assess their frailty status and explore transitions between frailty
C. Won, Seoyoon Lee, Jinhee Kim, D. Chon, Sunyoung Kim, Chang-O Kim, Mi Kyung Kim, B. Cho, K. Choi, E. Roh, H. Jang, S. Son, Jin-Hee Lee, Y. Park, Sam-Gyu Lee, B. Kim, H. Kim, Jaekyung Choi, H. Ga, Kee-Jae Lee, Yunhwan Lee, Miji Kim   +21 more
semanticscholar   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Cohort Profile: the Jerusalem longitudinal cohort study [PDF]

International Journal of Epidemiology, 2008
Whilst it has been suggested that about 25% of the variability in human longevity is attributed to genetic influences, the remaining 75% is consequent upon a complex interplay of biological, environmental, social and culturally determined factors. In rising to the challenge of understanding the complexities of human ageing, a valuable tool to emerge in
Eliana Ein-Mor, Jochanan Stessman, Michael Bursztyn, Daniel Azoulay, Jeremy M. Jacobs, Aaron Cohen   +5 more
openaire   +3 more sources

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Associations of Longitudinal Fetal Growth Patterns With Cardiometabolic Factors at Birth

Frontiers in Endocrinology, 2021
BackgroundBirth weight is associated with cardiometabolic factors at birth. However, it is unclear when these associations occur in fetal life. We aimed to investigate the associations between fetal growth in different gestational periods and cord blood ...
Jia-Shuan Huang, Jia-Shuan Huang, Qiao-Zhu Chen, Si-Yu Zheng, Si-Yu Zheng, Rema Ramakrishnan, Ji-Yuan Zeng, Ji-Yuan Zeng, Can-Peng Zhuo, Can-Peng Zhuo, Yu-Mian Lai, Ya-Shu Kuang, Jin-Hua Lu, Jin-Hua Lu, Jian-Rong He, Jian-Rong He, Jian-Rong He, Xiu Qiu, Xiu Qiu   +18 more
doaj   +1 more source

Cohort Profile: Shahroud Eye Cohort Study [PDF]

International Journal of Epidemiology, 2012
The Shahroud Eye Cohort Study was set up to determine the prevalence and incidence of visual impairment and major eye conditions in the 40-64-year-old population of Shahroud as a Middle Eastern population. The first phase of the study was conducted in 2009-10.
Hassan Koohian, Mohammad Reza Khademi, Mehdi Mirzaii, Ebrahim Jafarzadehpur, Mohammad Shariati, Ahmad Kheirkhah, Mehdi Khabazkhoob, Kamran Hodjatjalali, Sarvenaz Malihi, Kamran Yazdani, Reza Chaman, Akbar Fotouhi, Hassan Hashemi, Mohammad Hassan Emamian   +13 more
openaire   +3 more sources

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Associations between maternal pre-pregnancy BMI and infant striatal mean diffusivity

BMC Medicine
Background It is well-established that parental obesity is a strong risk factor for offspring obesity. Further, a converging body of evidence now suggests that maternal weight profiles may affect the developing offspring’s brain in a manner that confers ...
Aylin Rosberg, Harri Merisaari, John D. Lewis, Niloofar Hashempour, Minna Lukkarinen, Jerod M. Rasmussen, Noora M. Scheinin, Linnea Karlsson, Hasse Karlsson, Jetro J. Tuulari   +9 more
doaj   +1 more source