Results 121 to 130 of about 790,002 (307)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Towards multimodal interactions in the multilingual EFL classroom: Lessons from a COIL experience

Indonesian Journal of Applied Linguistics, 2019
Internationalization of higher education has recently gained momentum, and many tertiary education institutions have felt it incumbent upon themselves to foster this trend.
Sajjad Pouromid
doaj   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Tracing the Filamentary Structure of the Galaxy Distribution at z~0.8

, 2010
We study filamentary structure in the galaxy distribution at z ~ 0.8 using data from the Deep Extragalactic Evolutionary Probe 2 (DEEP2) Redshift Survey and its evolution to z ~ 0.1 using data from the Sloan Digital Sky Survey (SDSS). We trace individual
Abazajian, Alison L. Coil, Aragón-Calvo, Bharadwaj, Blanton, Blanton, Blanton, Blanton, Bond, Bond, Bond, Brown, Christopher N. A. Willmer, Cohen, Coil, Coil, Coil, Coil, Connolly, Conroy, Davis, De Lapparent, Ena Choi, Eriksen, Faber, Forero-Romero, Fukugita, Geller, Giavalisco, Gott, Gunn, Gunn, Ivezić, Lacoste, Le Fèvre, Marc Davis, Meneux, Michael A. Strauss, Moody, Nicholas A. Bond, Novikov, Ouchi, Phleps, Schechter, Smith, Sousbie, Sousbie, Sousbie, Stoica, Stoica, Stoughton, Strauss, Willmer, York, Zel'Dovich   +54 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Reducing systematic errors in time-frequency resolved mode number analysis

, 2015
The present paper describes the effect of magnetic pick-up coil transfer functions on mode number analysis in magnetically confined fusion plasmas. Magnetic probes mounted inside the vacuum chamber are widely used to characterize the mode structure of ...
Horváth, L., Maraschek, M., Papp, G., Pokol, G. I., Poloskei, P. Zs., Schuhbeck, K. H.   +5 more
core   +1 more source

Impacto de la Metodología “Aprendizaje Colaborativo Internacional en Línea” (COIL) en el Aprendizaje de Capacitancia en Estudiantes de Ingeniería [PDF]

Revista Entropía Educativa
El auge de la educación transnacional y los avances tecnológicos han significado un despunte en el intercambio virtual (VE, por sus siglas en inglés) en general y en el aprendizaje colaborativo internacional en línea (COIL, por sus siglas en inglés) en ...
Kim Alejandro Soriano Jiménez
doaj  

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source