Results 61 to 70 of about 423,267 (304)
Gazi Üniversitesi Fen Bilimleri Dergisi, 2021 In this paper, an encircling probe design used in the inspection of conductive wires, which are qualified as aluminum clad steel (ACS) wire is made. The eddy current systems are widely used for the quality control of conductive materials as one of non ...
Halim Burak TAŞKIN +1 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Flipper coil closure of patent ductus arteriosus [PDF]
, 2007 Transcatheter closure of patent ductus arteriosus is now a well established therapeutic option. In this paper, we illustrate step by step the technique of Flipper coil closure of small (
DeGiovanni, Joseph V., Grech, Victor E.
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Structural determinants of coiled coil mechanics
Physical Chemistry Chemical Physics, 2019 In shear geometry, the sequence–structure–mechanics relationship of rationally designed coiled coil heterodimers is determined by the helix propensity of the individual helices and the packing density at the hydrophobic core.
Patricia Lopez-Garcia +5 more
openaire +4 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Structural specificity in coiled-coil interactions [PDF]
Current Opinion in Structural Biology, 2008 Coiled coils have a rich history in the field of protein design and engineering. Novel structures, such as the first seven-helix coiled coil, continue to provide surprises and insights. Large-scale datasets quantifying the influence of systematic mutations on coiled-coil stability are a valuable new asset to the area.
Gevorg, Grigoryan, Amy E, Keating
openaire +2 more sources
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
On-Surface Assembly of Coiled-Coil Heterodimers [PDF]
Langmuir, 2012 The coiled coil is a widespread protein motif responsible for directing the assembly of a wide range of protein complexes. To date, research has focused largely on the solution phase assembly of coiled-coil complexes. Here, we describe an investigation into coiled-coil heterodimer assembly where one of the peptides is immobilized directly onto a gold ...
Simon J, White +7 more
openaire +2 more sources
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source