Results 81 to 90 of about 876,730 (357)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Flux sensing device using a tubular core with toroidal gating coil and solenoidal output coil wound thereon Patent [PDF]
, 1965 Flux gate magnetometer with toroidal gating coil and solenoidal output coil for signal modulation or ...
Ling, S. C.
core +1 more source
Neutron Resonance Spin Flippers: Static Coils Manufactured by Electrical Discharge Machining
, 2014 Radiofrequency spin flippers (RFSF) are key elements of Neutron Resonance Spin Echo (NRSE) spectrometers, which allow performing controlled manipulations of the beam polarization.
Böni, P. +6 more
core +1 more source
Inhibiting epidermal growth factor receptor at a distance. [PDF]
, 2014 The epidermal growth factor receptor (EGFR) tyrosine kinase is implicated in a large number of human cancers. Most EGFR inhibitors target the extracellular, growth factor-binding domain or the intracellular, ATP-binding domain. Here we describe molecules
Denton, Elizabeth +2 more
core +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Frontiers in Cardiovascular MedicinePurposeThis study aimed to evaluate the efficacy and safety of ethanol embolization in treating traumatic arteriovenous fistulas (TAVFs).Materials and methodsFrom March 2012 to April 2020, 42 consecutive patients (29.9 ± 15.1 years, range: 3–68 years ...
Yuchen Shen +6 more
doaj +1 more source
RF inductor has high Q, is stable at higher temperatures [PDF]
, 1967 Encapsulated RF inductor with an insulated coil has a high Q and remains stable for long periods of time at high temperatures. The coil is wound on a core and both are encapsulated in an epoxy resin.
Wiler, E. M.
core +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Shaft transducer having dc output proportional to angular velocity [PDF]
, 1984 A brushless dc tachometer is disclosed that includes a high strength toroidal permanent magnet for providing a uniform magnetic field in an air gap, an annular pole piece opposite the magnet, and a pickup coil wound around the pole piece and adapted to ...
Handlykken, M. B.
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source