Results 261 to 270 of about 410,815 (307)
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A Designed Heterotrimeric Coiled Coil
Biochemistry, 1995Principles that guide folding of coiled coils were tested by designing three peptides that preferentially associate with each other to form a heterotrimeric coiled coil. The core positions of the designed helices contained residues that promote formation of trimeric coiled coils.
S, Nautiyal +3 more
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Designing the Folding Mechanics of Coiled Coils
ChemPhysChem, 2009AbstractNaturally occurring coiled coils are often not homogeneous throughout their entire structure but rather interrupted by sequence discontinuities and non‐coiled‐coil‐forming subsegments. We apply atomic force microscopy to locally probe the mechanical folding/unfolding process of a well‐understood model coiled coil when unstructured subsegments ...
Thomas, Bornschlögl +2 more
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De novo design of heterotrimeric coiled coils
Biopolymers, 1996The three-helix bundle is a common structural motif among natural proteins. It has been observed in numerous important proteins, such as fibrinogen, laminin, spectrin, dystrofin, hemagglutinin, and mannose binding proteins. The three-helix bundle is a simple structure in which three alpha-helices pack against each other, with a slight left-handed twist.
LOMBARDI, ANGELINA +2 more
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Gradient coil design: A review of methods
Magnetic Resonance Imaging, 1993Methods of coil design for MRI gradient coils and other purposes are discussed. The conflicting requirements for satisfactory gradient coil performance are described and analyzed. Design methods are classified into discrete wire techniques and current density techniques.
Robert Turner
exaly +4 more sources
Design and stability of a novel coiled-coil peptide
International Journal of Biological Macromolecules, 2007According to a template of natural protein, a novel peptide was designed with satisfied stability which came from the formation of coiled-coil dimer in vitro. The knowledge gained from this study is not only useful in antiparallel coiled-coil designing but also provide an ideal antiparallel coiled-coil model in future research.
Xiang, Wei +2 more
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Peptide ‘Velcro’: Design of a heterodimeric coiled coil
Current Biology, 1993The leucine zipper is a protein structural motif involved in the dimerization of a number of transcription factors. We have previously shown that peptides corresponding to the leucine-zipper region of the Fos and Jun oncoproteins preferentially form heterodimeric coiled coils, and that simple principles involving electrostatic interactions are likely ...
E K, O'Shea, K J, Lumb, P S, Kim
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Design and Characterization of a Homodimeric Antiparallel Coiled Coil
Journal of the American Chemical Society, 2003We report the first successful design of a self-associating antiparallel coiled coil, APH. The simultaneous application of Coulombic and hydrophobic components results in a decided preference for the antiparallel alignment as judged by HPLC, sedimentation equilibrium, and chemical denaturation data.
Daniel G, Gurnon +2 more
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Coiled-Coil Protein Origami: Design, Isolation, and Characterization
2023Coiled-coil protein origami (CCPO) is a rationally designed de novo protein fold, constructed by concatenating coiled-coil forming segments into a polypeptide chain, that folds into polyhedral nano-cages. To date, nanocages in the shape of a tetrahedron, square pyramid, trigonal prism, and trigonal bipyramid have been successfully designed and ...
Žiga, Strmšek +3 more
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Thermodynamic Analysis of a Designed Three-Stranded Coiled Coil
Biochemistry, 1996The study and successful design of coiled-coil protein structural motifs have provided much insight into the rules governing protein folding and stability. In this work we use a thermodynamic approach to quantitate the rules that govern the specific oligomerization of coiled coils. We have designed a highly stable trimeric coiled coil by placing valine
Boice, Judith A. +3 more
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Considerations in the Design and Optimization of Coiled Coil Structures
2006Coiled coil motifs are, despite their apparent simplicity, highly specific, and play a significant role in the understanding of tertiary structure and its formation. The most commonly observed of the coiled coils, the parallel dimeric, is yet to be fully characterized for this structural class in general.
Mason, Jody M. +2 more
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