Results 271 to 280 of about 410,815 (307)
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Design and Characterization of an Intramolecular Antiparallel Coiled Coil Peptide
Biochemistry, 1994A 56-residue polypeptide was designed to fold into a stable intramolecular antiparallel coiled coil, referred to as a coiled coil stem loop. The antiparallel orientation of the alpha-helices was dictated by the alignment of hydrophobic and ionic residues in the heptad repeat sequence (a, b, c, d, e, f, g)n.
D G, Myszka, I M, Chaiken
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Coiled-Coil Design: Updated and Upgraded
2017α-Helical coiled coils are ubiquitous protein-folding and protein-interaction domains in which two or more α-helical chains come together to form bundles. Through a combination of bioinformatics analysis of many thousands of natural coiled-coil sequences and structures, plus empirical protein engineering and design studies, there is now a deep ...
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Optimal coil array design: the two-coil case
Magnetic Resonance Imaging, 2007The optimization problem for coil arrays is largely unsolved, even for the case of a two-coil system. This paper reports a systematic computer simulation to investigate the maximal achievable signal-to-noise ratio (SNR) with a two-coil receiver system where, using cancellation circuitry, mutual inductance is made zero. Both symmetrical and asymmetrical
Pascal, Spincemaille +3 more
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Targeting Metastable Coiled-Coil Domains by Computational Design
Journal of the American Chemical Society, 2008Approximately 30% of eukaryotic genomes are predicted to encode partially unfolded proteins. Many of these unstructured domains contact multiple partners in short-lived interactions critical for cellular homeostasis. Understanding the functional implications of these transient binding events is a current challenge that could be addressed with designed ...
Patrick, Barth +2 more
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The Design of Coiled-Coil Structures and Assemblies
2005Protein design allows sequence-to-structure relationships in proteins to be examined and, potentially, new protein structures and functions to be made to order. To succeed, however, the protein-design process requires reliable rules that link protein sequence to structure?function.
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Helmholtz Coils and Coil Design
2013Summary Coils for producing both low and high magnetic fields and for the detection of weak fluctuating fields as in spinner magnetometers are discussed. Expansions of the field about the centre of a coil system are developed for cylindrical and square, symmetrical and antisymmetrical systems.
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Electrochemically Directed Assembly of Designer Coiled-Coil Telechelic Proteins
ACS Biomaterials Science & Engineering, 2017We report the design and characterization of a de novo electrogelation protein comprising a central spider silk glue motif flanked by terminal pH-triggered coiled-coil domains. The coiled-coiled domains were designed to form intramolecular helix bundles below a sharply defined pH-trigger point (∼pH 5.3), whereas the spider silk glue protein, because of
Yinan Lin +5 more
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Design, Folding, and Activities of Metal-Assembled Coiled Coil Proteins
Inorganic Chemistry, 2004Metal ions serve many purposes in natural proteins, from the stabilization of tertiary structure to the direction of protein folding to crucial roles in electron transfer and catalysis. There is considerable interest in creating metal binding sites in designed proteins to understand the structural role of metal ions and to design new metalloproteins ...
Allison J, Doerr, George L, McLendon
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Design of two-stranded and three-stranded coiled-coil peptides
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1995Abstract The structural features required for the formation of two- versus three-stranded coiled coils have been explored using de novo protein design. Peptides with leucine at the ‘a’ and ‘d’ positions of a coiled-coil (general sequence: Leua Xaab Xaac Leud Glue Xaaf Lysg) exist in a non-cooperative equilibrium between unstructured ...
Betz, Stephen +4 more
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The design of deflection coils
Journal of Physics D: Applied Physics, 1977The relation between the deflection aberrations and winding distribution of a scanning system is briefly reviewed and the importance of the cosine-distributed coil is pointed out. The winding distribution of the saddle-type deflection coil is completely Fourier-analysed, including the end effect and formulae are given for calculating the Fourier ...
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