Results 71 to 80 of about 16,876 (264)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Impact of aneurysm sac size on the effectiveness of endovascular coiling in patient-specific middle cerebral artery aneurysms: a computational study

Scientific Reports
This study investigates the hemodynamic efficiency of endovascular coiling in the treatment of patient-specific middle cerebral artery (MCA) aneurysms using computational models of both original and scaled-down geometries.
Zhichao Yao, Hao Wen
doaj   +1 more source

Abstract 11: Impact of Umbilical Coiling Index on Perinatal Outcomes

Preventive Medicine: Research & Reviews
Background: The umbilical coiling index (UCI), defined as the ratio of vascular coils to cord length, has been proposed as an indicator of fetal well-being.
Alwi Zaman, Katyayani, Ayesha Ahmad, Suman Nishad   +3 more
doaj   +1 more source

Influence of parent vessel feature on the risk of internal carotid artery aneurysm rupture via computational method

Scientific Reports, 2023
In this study, the role of sac section area and parent vessel diameter on the hemodynamic feature of the blood flow in selected internal carotid artery (ICA) aneurysms is comprehensively investigated.
Mehdi Fattahi, Seyyed Amirreza Abdollahi, Ali Hosin Alibak, Saleh Hosseini, Phuyen Dang   +4 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Fertimetro, a Principle and Device to Measure Soil Nutrient Availability for Plants by Microbial Degradation Rates on Differently-Spiked Buried Threads [PDF]

, 2018
A novel patented method (PCT/IB2012/001157: Squartini, Concheri, Tiozzo, University of Padova) and the corresponding application devices, suitable to measure soil fertility, are presented. The availability or deficiency of specific nutrients for crops is
Berti, A., Borin, M., Concheri, G., Morari, F., Polese, R., Squartini, A., Stevanato, P., Tiozzo, S.   +7 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Antenatal Umbilical Cord Coiling Index and Adverse Perinatal Outcome: A Prospective Observational Study at A Tertiary Care Hospital in Multan

Life and Science
Objective: The study aims to determine the association between antenatal umbilical cord coiling index (aUCI) measured by Color Doppler ultrasonography in the late second trimester and adverse perinatal outcomes.
Atif Latif, Shabeeh e Zahra, Sadaf Aziz, Mubashrah Aziz, Nausheen Sadiq, Ammara Iftkhar   +5 more
doaj   +1 more source

MRI Vessel Wall Imaging and Treatment of an Aneurysm at the Atlanto-Axial Segment of an Aberrant Vertebral Artery [PDF]

Neurointervention, 2018
We report a case of unique location of an aneurysm at the atlanto-axial extradural segment of a unilateral aberrant vertebral artery. The MRI vessel wall imaging findings and possible mechanism of aneurysm formation were discussed.
Tsang Chun On Anderson, Yeung Wan Lung Ryo, Mak Ka Fung, Lui Wai Man   +3 more
doaj   +1 more source

Characterization of avirulent mutant Legionella pneumophila that survive but do not multiply within human monocytes. [PDF]

, 1987
Legionella pneumophila, the causative agent of Legionnaires' disease, is a Gram-negative bacterium and a facultative intracellular parasite that multiplies in human monocytes and alveolar macrophages. In this paper, mutants of L.
Horwitz, MA
core