Results 231 to 240 of about 45,519 (269)
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Circulation
BACKGROUND: Colchicine has been approved to reduce cardiovascular risk in patients with coronary heart disease on the basis of its potential benefits demonstrated in the COLCOT (Colchicine Cardiovascular Outcomes Trial) and LoDoCo2 (Low-Dose Colchicine 2)
Miao Yu +12 more
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BACKGROUND: Colchicine has been approved to reduce cardiovascular risk in patients with coronary heart disease on the basis of its potential benefits demonstrated in the COLCOT (Colchicine Cardiovascular Outcomes Trial) and LoDoCo2 (Low-Dose Colchicine 2)
Miao Yu +12 more
semanticscholar +1 more source
Joint Bone Spine, 2006
Colchicine is used chiefly in the treatment of gout but is also valuable in other inflammatory diseases such as familial Mediterranean fever (FMF). Three proteins play pivotal roles in colchicine pharmacokinetics: the colchicine receptor, tubulin, which governs the plasma elimination half-life of the drug; intestinal and hepatic CYP3A4, which is key to
Elisabeth, Niel, Jean-Michel, Scherrmann
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Colchicine is used chiefly in the treatment of gout but is also valuable in other inflammatory diseases such as familial Mediterranean fever (FMF). Three proteins play pivotal roles in colchicine pharmacokinetics: the colchicine receptor, tubulin, which governs the plasma elimination half-life of the drug; intestinal and hepatic CYP3A4, which is key to
Elisabeth, Niel, Jean-Michel, Scherrmann
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Annals of the New York Academy of Sciences, 2009
Purified from a Mediterranean plant nearly two centuries ago, colchicine has been discovered to inhibit many steps in the inflammatory process. The drug has good oral bioavailability and some enterohepatic recirculation, requiring dose adjustments for kidney disease and avoidance in liver disease. Toxicities are primarily gastrointestinal, hepatic, and
Anupama, Bhat +3 more
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Purified from a Mediterranean plant nearly two centuries ago, colchicine has been discovered to inhibit many steps in the inflammatory process. The drug has good oral bioavailability and some enterohepatic recirculation, requiring dose adjustments for kidney disease and avoidance in liver disease. Toxicities are primarily gastrointestinal, hepatic, and
Anupama, Bhat +3 more
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Trends in Cardiovascular Medicine, 2015
Colchicine is one of the oldest available drugs. It has been used for centuries to treat and prevent gouty attacks and more recently to prevent attacks of autoinflammatory diseases such as Familial Mediterranean Fever. Its main mechanism of action is the capability to block the polymerization of tubulin, thus affecting the function of microtubules. The
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Colchicine is one of the oldest available drugs. It has been used for centuries to treat and prevent gouty attacks and more recently to prevent attacks of autoinflammatory diseases such as Familial Mediterranean Fever. Its main mechanism of action is the capability to block the polymerization of tubulin, thus affecting the function of microtubules. The
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Colchicine Alkaloids, and Synthetic Analogues: Current Progress and Perspectives.
Journal of Medicinal Chemistry, 2020Colchicine, the main alkaloid of Colchicum autumnale, is one of the most famous natural molecules. Although colchicine belongs to the oldest drugs (being in use since 1500 BC), its pharmacological potential as a lead structure is not yet fully exploited.
I. Gracheva +4 more
semanticscholar +1 more source
Scandinavian Journal of Rheumatology, 1996
Colchicine myopathy typically presents as painless muscle weakness. This report describes a post renal-transplant patient who presented with pain in both extremities bilaterally that was refractory to narcotic analgesics. He had been on low dose daily colchicine for 7 years. Laboratory, EMG, and biopsy findings all supported the diagnosis of colchicine
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Colchicine myopathy typically presents as painless muscle weakness. This report describes a post renal-transplant patient who presented with pain in both extremities bilaterally that was refractory to narcotic analgesics. He had been on low dose daily colchicine for 7 years. Laboratory, EMG, and biopsy findings all supported the diagnosis of colchicine
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The Journal of Emergency Medicine, 1994
Colchicine poisoning is an unusual but serious form of drug intoxication. Although relatively uncommon, colchicine poisoning may produce life-threatening systemic effects that must be recognized and treated by the emergency physician. This alkaloid found in Colchicum autumnale is used primarily in the treatment of gout.
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Colchicine poisoning is an unusual but serious form of drug intoxication. Although relatively uncommon, colchicine poisoning may produce life-threatening systemic effects that must be recognized and treated by the emergency physician. This alkaloid found in Colchicum autumnale is used primarily in the treatment of gout.
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Experientia, 1953
Expose d'une nouvelle hypothese sur l'origine biochimique de la colchicine dans la plante. Il est suppose que l'acide trihydroxyphenylpyruvique agit commeprecurseur de cet alcaloide en subissant les transformations decrites par les formules (I) a (VI).
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Expose d'une nouvelle hypothese sur l'origine biochimique de la colchicine dans la plante. Il est suppose que l'acide trihydroxyphenylpyruvique agit commeprecurseur de cet alcaloide en subissant les transformations decrites par les formules (I) a (VI).
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JCR: Journal of Clinical Rheumatology, 1996
Colchicine myopathy can complicate standard treatment of gout, especially in those patients with underlying renal insufficiency. The symptoms of this disorder are frequently insidious, and the diagnostic tests used in its evaluation are mostly nonspecific.
D S, Uri, M, Biavis
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Colchicine myopathy can complicate standard treatment of gout, especially in those patients with underlying renal insufficiency. The symptoms of this disorder are frequently insidious, and the diagnostic tests used in its evaluation are mostly nonspecific.
D S, Uri, M, Biavis
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Studies on Colchicine, Colchicine Derivatives, and Endotoxin in Irradiated Animals
Radiation Research, 1962Colchicine when given 3, 2, or 1 day and trimethylcolchicinic acid methyl ether, colchiceinamide, colchiceine, and N-acetylcolchinol when given 1 day before irradiation caused an increase in survival of mice, provided they were more than 7 weeks old and the radiation dose one which causes death in approximately 1 to 4 weeks.
Smith, W W, Alderman, I M
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