Results 51 to 60 of about 295 (207)

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

A Comparative Analysis of the Synoptic Conditions and Thermodynamics of Two Thundersnow Weather Events in Shaanxi Province, China, During 2023

Atmosphere
This study presents a comparative analysis of two rare thundersnow events accompanied by snowfall that occurred on 11 November 2023 and 10 December 2023 in Shaanxi province, China. Multiple data sources were integrated, including MICAPS surface and upper-
Yueqi Li, Hongbo Ni, Jialu Liu, Yan Chou, Xinkai Hao, Shaoyang Liu   +5 more
doaj   +1 more source

Mesoscale numerical simulations of heavy nocturnal rainbands associated with coastal fronts in the Mediterranean Basin [PDF]

Natural Hazards and Earth System Sciences, 2014
Three offshore rainbands associated with nocturnal coastal fronts formed near the Israeli coastline, the Gulf of Genoa and on the northeastern coast of the Iberian Peninsula, are simulated using version 3.3 of the WRF-ARW mesoscale model in order to ...
J. Mazon, D. Pino
doaj   +1 more source

The effect of sidewall forest canopies on the formation of cold‐air pools: A numerical study [PDF]

Journal of Geophysical Research: Atmospheres, 2013
While the evolution and dynamics of cold‐air pools in basins and valleys continue to be an active area of research, the influence of vegetation cover on cold‐air pools remains largely unexamined. Recently, the Advanced Regional Prediction System (ARPS) atmospheric model has been modified to allow simulation of flow through a multilayer canopy (ARPS ...
M. T. Kiefer, S. Zhong
openaire   +1 more source

Soil Inorganic Electron Acceptors and Carbon Substrates Hierarchically Govern Wetland Methanogenesis Temperature Response

Advanced Science, EarlyView.
ABSTRACT Wetlands constitute Earth's largest natural methane (CH4) source, yet projections of their climate feedback remain uncertain due to poorly constrained temperature sensitivity (Q10‐CH4) of microbial methanogenesis. While water table dynamics have been demonstrated to regulate wetland methanogenesis by altering key soil conditions such as ...
Shuying Qiu, Qingfang Jing, Xuhui Zhou, Xiaoxin Sun, Zhenyu Wei, Baizhi Jiang, Hongyang Chen   +6 more
wiley   +1 more source

Interactions between downslope flows and a developing cold-air pool

, 2015
Downslope flows and regions of enhanced cooling have important impacts on society and the environment. Parameterisation of these often subgrid-scale phenomena in numerical models requires a sound understanding of the underlying physical processes, which has been the overarching aim of this work.
  +7 more sources

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Frequent and strong cold‐air pooling drives temperate forest composition

Ecology and Evolution
AbstractCold‐air pooling is an important topoclimatic process that creates temperature inversions with the coldest air at the lowest elevations. Incomplete understanding of sub‐canopy spatiotemporal cold‐air pooling dynamics and associated ecological impacts hinders predictions and conservation actions related to climate change and cold‐dependent ...
Melissa A. Pastore, Aimée T. Classen, Anthony W. D'Amato, Marie E. English, Karin Rand, Jane R. Foster, E. Carol Adair   +6 more
openaire   +3 more sources

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

Mesoscale atmospheric processes over an Arctic fjord as observed during a research aircraft campaign in winter

Polar Research
Unique research aircraft observations were conducted within an Arctic fjord in Svalbard during three days in March 2013. Wijdefjorden is 110 km long, 5–15 km wide and has a north–south axis.
Irene Suomi, Timo Vihma, Tiina Nygård, Jörg Hartmann, Christof Lüpkes   +4 more
doaj   +1 more source