Results 81 to 90 of about 3,999,655 (320)

Impact of Cold Climates on Vehicle Emissions: The Cold Start Air Toxics Pulse [PDF]

, 2016
This project measured cold start emissions from four vehicles in winter using fast response instrumentation to accurately measure the time variation of the cold start emission pulse.
Huangfu, Yibo, Jobson, Tom
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Exploiting synergy between ontologies and recommender systems [PDF]

, 2002
Recommender systems learn about user preferences over time, automatically finding things of similar interest. This reduces the burden of creating explicit queries.
Alani, Harith, Middleton, Stuart E., Roure, David C. De, Shadbolt, Nigel R.   +3 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Mutagenicity assessment of aerosols in emissions from wood combustion [PDF]

, 2011
Mestrado em Estudos AmbientaisPolycyclic aromatic hydrocarbon (PAH) extracts of PM2.5 collected from combustion of seven wood species and briquettes were tested for mutagenic activities using Ames test with Salmonella typhimurium TA98 and TA100.
Binh Ngan Vu
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A Novel Framework Leveraging Large Language Models to Enhance Cold-Start Advertising Systems

Future Internet
The cold-start problem remains a critical challenge in personalized advertising, where users with limited or no interaction history often receive suboptimal recommendations.
Albin Uruqi, Iosif Viktoratos, Athanasios Tsadiras   +2 more
doaj   +1 more source

Using Posters to Recommend Anime and Mangas in a Cold-Start Scenario

, 2017
Item cold-start is a classical issue in recommender systems that affects anime and manga recommendations as well. This problem can be framed as follows: how to predict whether a user will like a manga that received few ratings from the community? Content-
Chalumeau, Thomas, Clement, Basile, Cocchi, Kévin, Kashima, Hisashi, Lahfa, Ryan, Vie, Jill-Jênn, Yger, Florian   +6 more
core   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Scalable Cold-Start Optimization in Serverless Computing: Leveraging Function Fusion With PanOpticon Simulator

IEEE Access
Serverless computing has transformed cloud computing with its inherent scalability, pay-as-you-go pricing model, and low-latency execution. However, cold-start delays arising from the on-demand initialization of execution environments such as containers ...
Ranjan Kumar Behera, Anisha Kumari, Sung-Bae Cho   +2 more
doaj   +1 more source