Results 161 to 170 of about 2,553,529 (294)

Uncertainty-Calibrated Collaborative Filtering via Heteroscedastic Bayesian Neural Networks. [PDF]

Entropy (Basel)
Wang X.
europepmc   +1 more source

The continuous cold start problem in e-commerce recommender systems

, 2015
Many e-commerce websites use recommender systems to recommend items to users. When a user or item is new, the system may fail because not enough information is available on this user or item.
Mueller, M.J.I., Bernardi, L., Kiseleva, Y., Kamps, J.   +3 more
core  

In Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma

Advanced Science, EarlyView.
By employing in vivo CRISPR functional screening, we identify ribosomal protein RPS19 as a pivotal mediator driving immune evasion in hepatocellular carcinoma, wherein tumor‑released RPS19 binds C5aR1 on tumor‑associated macrophages to initiate downstream immunosuppressive signaling; SP94‑peptide‑modified SNPSS nanoparticles deliver Cas9/sgRPS19 ...
Lei He, Duo Yu, Fei Xie, Kaisheng Hou, Zhaozhao Li, Meifang Dai, Jingyi Yun, Haiyan Cao, Yang Xiao, Yueyuan Qiu, Gege Shi, Wangqian Zhang, Shuning Wang, Qiang Hao, Jieyu Zhang, Zhaowei Wang, Yingqi Zhang, Kuo Zhang, Jintao Gu, Haichen Du, Meng Li   +20 more
wiley   +1 more source

A multi-task learning-based fully connected neural network for personalized news recommendation. [PDF]

Sci Rep
Ren Z, Xie H.
europepmc   +1 more source

Melatonin Mitigates Doxorubicin‐Induced Cardiotoxicity by Targeting the USP18/PKM2 Axis Without Compromising Antitumor Efficacy

Advanced Science, EarlyView.
Melatonin engages MT1/MT2 receptors to suppress STAT1‐driven USP18 upregulation, thereby redirecting PKM2 ubiquitination from K33‐linked autophagic degradation toward K27‐linked nuclear translocation. This prevents PKM2‐mediated proinflammatory gene expression in the heart, alleviating doxorubicin‐induced cardiotoxicity without compromising antitumor ...
Zhenyu Feng, Yijin Yang, Jie Bai, Pengqi Sun, Xuyang Sun, Jinshu Shang, Yang Liu, Zhen Ning, Ningning Zhang, Yun‐long Xia, Yunpeng Xie   +10 more
wiley   +1 more source

A Mechanistic Dissection of Multifaceted Complement Attack in Age‐Related Macular Degeneration Reveals the Superiority of C3 Inhibition

Advanced Science, EarlyView.
Complement‐mediated RPE degeneration extends beyond terminal MAC injury. A four‐hit mechanism emerges in which C3a and C5a disrupt mitochondrial function, while C3b and MAC compromise the phagolysosomal system. Upstream C3 inhibition suppresses this full spectrum of pathogenic effectors, providing broader cellular protection than C5 blockade.
Zhidong Chen, Mingshuang Wang, Huiqin Liu, Feng Qian   +3 more
wiley   +1 more source

A Human-Centred Framework for Retrieval-Grounded Cold-Start Recommendation

Cold-start remains a fundamental limitation of recommender systems, particularly when no interaction history is available at first use. In knowledge-intensive domains, this issue is further exacerbated by the inability of existing approaches to exploit
Stefano Valtolina, Ricardo Anibal Matamoros, Francesco Epifania   +2 more
core   +1 more source

CRAFT: cold-start recommender with attention and federated training. [PDF]

Sci Rep
Sivakumar N, John RS, Bijo A, Suganeshwari G, Anbalagan S, Thandapani S.   +5 more
europepmc   +1 more source

Targeting Mitochondrial Redox Signaling Promotes Neuroregeneration and Functional Recovery in a Multiple Sclerosis Model

Advanced Science, EarlyView.
Modulation of mitochondrial redox signaling by furapyrrodole activates CYB5R3 and suppresses Notch signaling, unlocking the regenerative potential of endogenous neural progenitor cells. This approach promotes neurogenesis, oligodendrogenesis, and remyelination, thereby improving neuronal function in a mouse model of multiple sclerosis and identifying ...
Yuki Narushima, Joshua Saylor, Shun Saito, Jinyan Zhou, Haruka Kawano, Shehata Anwar, Haruki Oba, Rachel Huezo, Miyu Okano, Haruki Matsuda, Makoto Kawatani, Kaori Honda, Hiroyuki Osada, Yuta Kikuchi, Masahito Ohue, Masami Ishibashi, Takayoshi Arai, Makoto Inoue, Midori A. Arai   +18 more
wiley   +1 more source

Algorithmic advances in smart TV content recommendation: a structured evidence-mapping review. [PDF]

Front Big Data
Chen Z, He J, Gong Y, Liang J, Li J.
europepmc   +1 more source