Results 81 to 90 of about 1,121,070 (292)
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
Brown adipose tissue harbors a distinct sub-population of regulatory T cells.
PLoS ONE, 2015 Regulatory T (Treg) cells are critical determinants of both immune responses and metabolic control. Here we show that systemic ablation of Treg cells compromised the adaptation of whole-body energy expenditure to cold exposure, correlating with ...
Dasa Medrikova +9 more
doaj +1 more source
North American Workshop on Laser Ablation 2017: May 25-27, Austin [PDF]
, 2017 We are pleased to present the Abstract Book for the 2nd North American Workshop on Laser Ablation (NAWLA’17). NAWLA is a new biennial meeting with the mission to transfer laser ablation knowledge between specialists and promote a sense of community among
North American Laser Ablation Workshop Organizing Committee
core +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Zhongguo Linchuang YixueRenal denervation (RDN) as an interventional approach for treating refractory hypertension has developed a variety of ablation strategies and different energy ablation techniques. This article reviews the principles, characteristics, clinical advantages,
Li WANG, Xiaoqiang SUN, Chengzhi LU
doaj +1 more source
CDK7 Mediates the Beta-Adrenergic Signaling in Thermogenic Brown and White Adipose Tissues
iScience, 2020 Summary: Cyclin-dependent kinases (CDKs) are emerging regulators of adipose tissue metabolism. Here we aimed to explore the role of CDK7 in thermogenic fat. We found that CDK7 brown adipose tissue (BAT)-specific knockout mice (Cdk7bKO) have decreased BAT
Honglei Ji +9 more
doaj +1 more source
In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans
FEBS Open Bio, EarlyView.In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller +3 more
wiley +1 more source
BiomedicinesCatheter ablation has become a cornerstone therapy for atrial fibrillation, with pulmonary vein isolation as its mechanistic foundation. Radiofrequency ablation and cryoablation, the two established thermal technologies, have demonstrated robust efficacy
Andrei Mihordea +7 more
doaj +1 more source
Aerospace, 2018 The effect of thermal and chemical boundary conditions on the structure and chemical composition of the wake behind a 3D Mach 7 sphere-cone at an angle of attack of 5 degrees and an altitude of roughly 30,000 m is explored.
Matthew J. Satchell +2 more
doaj +1 more source