Results 61 to 70 of about 1,121,070 (292)
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Use of Radiofrequency Ablation in Benign Thyroid Nodules: A Literature Review and Updates
International Journal of Endocrinology, 2013 Successful thermal ablation using radiofrequency has been reported in various tumors including liver or kidney tumors. Nonsurgical minimally invasive ablative therapy such as radiofrequency ablation (RFA) has been reported to be a safe and efficient ...
Kai-Pun Wong, Brian Hung-Hin Lang
doaj +1 more source
Electrical conductivity measurement in Thiel-embalmed tissue model : relevance to radiofrequency ablation [PDF]
, 2014 PA gratefully acknowledges SUPA for funding his Advanced Research Fellowship.Thiel-embalmed human cadaveric specimens are used widely for biomedical scientific investigation.
Andre, P. +12 more
core +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
COMPARISON BETWEEN CARBONDIOXIDE LASER AND COLD INSTRUMENTS IN TREATMENT OF VOCAL NODULE
Pakistan Armed Forces Medical Journal, 2013 Background: Vocal cord nodules are one of the most frequent disorders in both children and adults who use their voice excessively. Main symptom with which patient presents is hoarseness of voice. The treatment in early stages is voice therapy.
Maj Nasir Akram Kundi +3 more
doaj +2 more sources
The multifaceted roles of lysosomes in cancer
Molecular Oncology, EarlyView.Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source
On testing laser ablation processes for asteroid deflection [PDF]
, 2011 Laser surface ablation has been theoretically demonstrated to be an advantageous method in the potential mitigation and deflection of Near Earth Asteroids.
Burns, David +3 more
core +2 more sources
Radiofrequency Ablation of Hepatic Malignancies: Is Heat Better Than Cold?
Annals of Surgery, 1999 The article by Curley and colleagues 1 in this issue of Annals of Surgery is notable for several reasons: 1) it is the largest patient series to date using radiofrequency ablation (RFA) for destruction of malignant neoplasms of the liver; 2) it is the first large clinical trial of combined RFA and a Pringle maneuver for control of tissue cooling; and 3)
David M. Mahvi, Fred T. Lee
openaire +2 more sources
Molecular Oncology, EarlyView.Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis +20 more
wiley +1 more source
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source