Clinical Hematology International, 2020 Cold agglutinin disease (CAD) is an uncommon form of cold autoimmune hemolytic anemia (AIHA). It should be considered in the differential diagnosis of elderly patients with unexplained chronic anemia presenting with or without cold-induced symptoms in ...
Amy P. Gabbard, Garrett S. Booth
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Sutimlimab for the Treatment of Cold Agglutinin Disease [PDF]
HemaSphere, 2023 Cold agglutinin disease (CAD) is a rare autoimmune hemolytic anemia and a bone marrow clonal lymphoproliferative disorder. Hemolysis in CAD is complement-dependent and mediated by the classical activation pathway.
Sigbjørn Berentsen
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Cold Agglutinin Disease – Diagnostic and Therapeutic Challenges in the Clinical Setting [PDF]
Documenta Haematologica, 2023 Cold agglutinin disease (CAD) is a rare form of autoimmune hemolytic anemia (AIHA), in which IgM-specific antibodies cause the agglutination of red blood cells (RBCs) at temperatures < 37°C and activate the classical pathway of complement leading to ...
Carmen SAGUNA +12 more
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Cold agglutinin-induced hemolytic anemia during room temperature fluid resuscitation: a case report
Journal of Medical Case Reports, 2021 Background Cold agglutinin disease can cause the agglutination of red blood cells and hemolytic anemia due to cold temperature. Herein, we report a case of progressive hemolytic anemia due to cold agglutinin disease during fluid resuscitation and in the ...
Yosuke Kawai +5 more
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Cold Agglutinin Syndrome as the Initial Presentation of Acute Myeloid Leukemia: A Case Report [PDF]
Clinical Case ReportsCold agglutinin‐mediated autoimmune hemolytic anemia, when secondary to viral and bacterial infections or, rarely, malignancy, is called cold agglutinin syndrome.
Mohsen Vakili Sadeghi +2 more
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A middle-aged woman with the initial symptom of acrocyanosis diagnosed with cold agglutinin disease: A case report [PDF]
SAGE Open Medical Case ReportsAutoimmune hemolytic anemia is when autoantibodies attack red blood cells, leading to anemia. Cold agglutinin disease, a subtype of autoimmune hemolytic anemia, accounts for 13%–32% of cases.
Babak Salimi +4 more
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Fatal cold agglutinin-induced haemolytic anaemia: a case report [PDF]
Journal of Medical Case Reports, 2010 Introduction Cold agglutinin disease usually develops as a result of the production of a specific immunoglobulin M auto-antibody directed against the I/i and H antigens, precursors of the ABH and Lewis blood group substances, on red blood cells ...
Reverberi Roberto +2 more
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Anesthesia Management of Cold Agglutinin Disease in a Pregnant Patient: A Case Report [PDF]
Clinical Case ReportsCold agglutinin disease (CAD), a rare autoimmune hemolytic anemia (AIHA), is characterized by hemolysis triggered by activation of the classical complement pathway. AIHA is estimated to affect one in 100,000 people in the general population; however, its
Jibran Ikram, Chase Jackson, Sabry Ayad
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Intracapillary Monoclonal IgM Deposition Concomitant With Cold Agglutinin Disease [PDF]
Kidney MedicineMonoclonal gammopathy of renal significance (MGRS) comprises a spectrum of kidney manifestations distinguished by its clinical and pathological presentations.
Silvia M. Titan +4 more
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Navigating cold agglutinin-induced hemolytic anemia in developing countries: A case report and literature review [PDF]
SAGE Open Medical Case ReportsCold agglutinin-induced hemolytic anemia presents diagnostic and management challenges, particularly in resource-limited settings like Pakistan. A 92-year-old male presented with altered consciousness, fever, weakness, and severe asthenia.
Ayesha Amjad +3 more
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