Results 11 to 20 of about 945,488 (321)

Sutimlimab in Cold Agglutinin Disease

New England Journal of Medicine, 2021
Cold agglutinin disease is a rare autoimmune hemolytic anemia characterized by hemolysis that is caused by activation of the classic complement pathway. Sutimlimab, a humanized monoclonal antibody, selectively targets the C1s protein, a C1 complex serine protease responsible for activating this pathway.We conducted a 26-week multicenter, open-label ...
Röth, Alexander, Barcellini, Wilma, D’Sa, Shirley, Miyakawa, Yoshitaka, Broome, Catherine M., Michel, Marc, Kuter, David J., Jilma, Bernd, Tvedt, Tor H.A., Frübis, Joachim, Jiang, Xiaoyu, Lin, Stella, Reuter, Caroline, Morales-Arias, Jaime, Hobbs, William, Berentsen, Sigbjørn   +15 more
openaire   +3 more sources

Cold Agglutinin Disease: Improved Understanding of Pathogenesis Helps Define Targets for Therapy

Hemato, 2022
The last 2 decades have seen great progress in understanding the pathogenesis of cold agglutinin disease (CAD) and development of effective therapies.
Sigbjørn Berentsen, Shirley D’Sa, Ulla Randen, Agnieszka Małecka, Josephine M. I. Vos   +4 more
doaj   +2 more sources

New Insights in the Pathogenesis and Therapy of Cold Agglutinin-Mediated Autoimmune Hemolytic Anemia

Frontiers in Immunology, 2020
Autoimmune hemolytic anemias mediated by cold agglutinins can be divided into cold agglutinin disease (CAD), which is a well-defined clinicopathologic entity and a clonal lymphoproliferative disorder, and secondary cold agglutinin syndrome (CAS), in ...
Sigbjørn Berentsen
doaj   +2 more sources

COVID-19 and Cold Agglutinin Hemolytic Anemia

TH Open, 2020
Novel coronavirus disease 2019 (COVID-19) has spread throughout the world and has infected close to 4 million people. It commonly presents with fever, cough, and fatigue. Due to the high inflammatory response, it is suggested that the coagulation cascade
Diana V. Maslov, Victoria Simenson, Suma Jain, Ambuga Badari   +3 more
doaj   +2 more sources

A Case of Primary Cold Agglutinin-Mediated Hemolytic Anemia Successfully Treated with Steroids [PDF]

Cureus
Raja T, Mayurathan P, Sabrina S.
europepmc   +3 more sources

SARS-CoV-2-associated cold agglutinin disease: a report of two cases [PDF]

Annals of Hematology, 2020
Dear Editor, Hematological manifestations reported in SARS-CoV-2 infection mainly include lymphocytopenia as a poor prognosis factor [1]. Thrombocytopenia can be associated with disseminated intravascular coagulation [2] or immune process [3].
Tessa Huscenot, J. Galland, Margot Ouvrat, Mathias Rossignol, Stéphane Mouly, D. Sène, on behalf of the APHP Lariboisière COVID Group   +6 more
openalex   +2 more sources

Sutimlimab for Cold Agglutinin Disease. [PDF]

J Adv Pract Oncol
Reid M, Fedutes Henderson BA.
europepmc   +3 more sources

Inhibition of complement C1s improves severe hemolytic anemia in cold agglutinin disease: a first-in-human trial [PDF]

Blood, 2018
Cold agglutinin disease is a difficult-to-treat autoimmune hemolytic anemia in which immunoglobulin M antibodies bind to erythrocytes and fix complement, resulting in predominantly extravascular hemolysis.
Ulrich Jäger, Shirley D’Sa, Christian Schörgenhofer, Johann Bartko, Ulla Derhaschnig, Christian Sillaber, Petra Jilma‐Stohlawetz, Michael Fillitz, Thomas Schenk, Gary Patou, Sandip Panicker, Graham C. Parry, James C. Gilbert, Bernd Jilma   +13 more
openalex   +2 more sources

Spinal Anesthesia in a Patient With Cold Agglutinin Disease Presenting for Total Knee Arthroplasty in a Community Hospital Setting. [PDF]

Cureus
Thiele C, Patel A, Johnson RL.
europepmc   +3 more sources

Cold Agglutinins and Cryoglobulins Associate With Clinical and Laboratory Parameters of Cold Urticaria

Frontiers in Immunology, 2021
Mast cell-activating signals in cold urticaria are not yet well defined and are likely to be heterogeneous. Cold agglutinins and cryoglobulins have been described as factors possibly associated with cold urticaria, but their relevance has not been ...
Mojca Bizjak, Mitja Košnik, Dorothea Terhorst-Molawi, Dejan Dinevski, Marcus Maurer   +4 more
doaj   +1 more source