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Cold Agglutinin Disease (CAD) is a rare type of autoimmune hemolytic anemia (AIHA) characterized by the unique property of IgM autoantibodies binding to red blood cells (RBCs) at low temperatures. Agglutination of RBCs and activation of complement are precursors to expression of clinical features manifested as ischemic changes and hemolysis.
Kathleen Bors, Maher Elharake MS
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Mast cell-activating signals in cold urticaria are not yet well defined and are likely to be heterogeneous. Cold agglutinins and cryoglobulins have been described as factors possibly associated with cold urticaria, but their relevance has not been ...
Mojca Bizjak +4 more
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Congenital cardiac surgery in a patient with cold agglutinins
Cold agglutinin disease is a type of autoimmune haemolytic anaemia caused by autoantibodies that bind to red blood cell antigens at a cold temperature and causes extravascular haemolysis and sometimes thrombosis also.
Mridul Agarwal +3 more
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Cold agglutinin-induced hemolytic anemia during room temperature fluid resuscitation: a case report
Background Cold agglutinin disease can cause the agglutination of red blood cells and hemolytic anemia due to cold temperature. Herein, we report a case of progressive hemolytic anemia due to cold agglutinin disease during fluid resuscitation and in the ...
Yosuke Kawai +5 more
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Background Cold agglutinin disease can lead to significant complications, especially for patients undergoing arch repair requiring hypothermic circulatory arrest. Rituximab and plasmapheresis are treatments for cold agglutinin disease.
Atsuyuki Mitsuishi +5 more
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Cold agglutinin disease, commonly affecting females in the their seventh decade of life, is otherwise a rare entity and has an incidence of one case per million people per year.
Vivek Ranjan +4 more
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Cold agglutinin syndrome in a patient with human immunodeficiency virus infection
A 44-year-old female with no prior comorbidities presented with a history of easy fatiguability and yellowish discolouration of eyes of 3 months duration. On examination, she had pallor and icterus. Jugular venous pressure was elevated.
Abhilash Naini +4 more
doaj +1 more source
A novel method for negating cold agglutination interference by dithiothreitol during complete blood count and peripheral blood smear: a case study [PDF]
Cold agglutinin disease is an autoimmune disorder that is characterized by antibodies attacking polysaccharide antigens on one’s own erythrocytes.
Hamit Yasar Ellidag +2 more
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Platelet Cold Agglutinins [PDF]
Abstract A "cold" platelet agglutinin is described which is present in plasma and serum, is greater than 100,000 in molecular weight, appears to be a protein of the immunoglobulin type, is adsorbed by platelets in the absence of bivalent cations, and reacts only at temperatures below 34°C.
N. Raphael Shulman, Stanley P. Watkins
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Is Splenectomy still the best treatment for Autoimmune hemolytic anemia
Introduction: Autoimmune hemolytic anemia (AIHA) is an acquired, heterogeneous group of diseases that includes AIHA with warm type antibodies, cold agglutinin disease (CAD), mixed type AIHA, paroxysmal cold hemoglobinuria, and atypical AIHA ...
Malwina Chomicz +9 more
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