Sutimlimab in Cold Agglutinin Disease
New England Journal of Medicine, 2021 Cold agglutinin disease is a rare autoimmune hemolytic anemia characterized by hemolysis that is caused by activation of the classic complement pathway. Sutimlimab, a humanized monoclonal antibody, selectively targets the C1s protein, a C1 complex serine protease responsible for activating this pathway.We conducted a 26-week multicenter, open-label ...
Röth, Alexander +15 more
openaire +3 more sources
Annals of Internal Medicine: Clinical Cases, 2023 Cold agglutinin disease is a rare autoimmune hemolytic anemia that preferentially affects female patients and is more common in those older than 60 years. The pathophysiology involves IgM autoantibodies against erythrocytes in areas of the body at cooler
David Aziz +5 more
doaj +1 more source
Use of Rituximab in autoimmune hemolytic anemia associated with non-hodgkin lymphomas [PDF]
, 2011 The association between non-Hodgkin lymphomas and autoimmune disorders is a well-known event. Also autoimmune hemolytic anemia (AHA), although much more frequent in patients with chronic lymphocytic leukemia (CLL), has been described in this group of ...
Fozza, Claudio +1 more
core +4 more sources
A novel method for demonstrating cold agglutinin disease: a case report
Journal of Medical Case Reports, 2018 Background Cold agglutinin disease is a rare disorder characterized by an autoimmune hemolytic anemia occurring at low temperatures. Physical examination findings, often limited to acrocyanosis, are combined with a thermal amplitude test to help ...
Thomas A. Vo +3 more
doaj +1 more source
Pseudoneutropenia from cold agglutinin leucoagglutination [PDF]
Journal of Clinical and Scientific Research, 2015 Pseudoneutropenia or low leucocyte count secondary to leucoagglutination is caused by ethylene diamine tetra acetic acid (EDTA) or cold agglutinins and is seen in benign and malignant disorders. We report a 34-year-old lady who was admitted with fever,
Momin M +6 more
doaj +1 more source
, 2018 This article answers the question: After ordering a type and screen I was notified by the blood bank that my patient has cold autoantibodies.
Coberly, Emily, Kneib, Jessica
core +1 more source
Overexpression of Nictaba-like lectin genes from glycine max confers tolerance towards Pseudomonas syringae infection, aphid infestation and salt stress in transgenic Arabidopsis plants [PDF]
, 2016 Plants have evolved a sophisticated immune system that allows them to recognize invading pathogens by specialized receptors. Carbohydrate-binding proteins or lectins are part of this immune system and especially the lectins that reside in the ...
Smagghe, Guy +2 more
core +6 more sources
Distribution of glycan motifs at the surface of midgut cells in the cotton leafworm (Spodoptera littoralis) demonstrated by lectin binding [PDF]
, 2017 Glycans are involved in many biological phenomena, including signal transduction, cell adhesion, immune response or differentiation. Although a few papers have reported on the role of glycans in the development and proper functioning of the insect midgut,
Els J. M. Van Damme +5 more
core +2 more sources
Clinical relevance of silent red blood cell autoantibodies. [PDF]
, 2017 .
Alessandri, C +14 more
core +1 more source
Cloning and expression of porcine β1,4 N-acetylgalactosaminyl transferase encoding a new xenoreactive antigen [PDF]
, 2014 Xenograft rejection of pigs organs with an engineered mutation in the GGTA-1 gene (GTKO) remains a predominantly antibody mediated process which is directed to a variety of non-Gal protein and carbohydrate antigens.
Byrne, GW +4 more
core +2 more sources