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Sutimlimab for Cold Agglutinin Disease. [PDF]

J Adv Pract Oncol
Cold agglutinin disease (CAD) is a rare type of autoimmune hemolytic anemia (AIHA) distinct from warm antibody AIHA. One of the ways it is distinct is that CAD is usually not responsive to corticosteroids compared with warm antibody AIHA. Historically, CAD therapy has been limited to immunotherapy or chemoimmunotherapy with varying responses.
Reid M, Fedutes Henderson BA.
europepmc   +5 more sources

Cold Agglutinin Disease [PDF]

Clinical Hematology International, 2020
Cold agglutinin disease (CAD) is an uncommon form of cold autoimmune hemolytic anemia (AIHA). It should be considered in the differential diagnosis of elderly patients with unexplained chronic anemia presenting with or without cold-induced symptoms in ...
Amy P. Gabbard, Garrett S. Booth
doaj   +5 more sources

Cold Agglutinin Disease – Diagnostic and Therapeutic Challenges in the Clinical Setting [PDF]

Documenta Haematologica, 2023
Cold agglutinin disease (CAD) is a rare form of autoimmune hemolytic anemia (AIHA), in which IgM-specific antibodies cause the agglutination of red blood cells (RBCs) at temperatures < 37°C and activate the classical pathway of complement leading to ...
Carmen SAGUNA, Alexandra Oana ENACHE, Maria BUBULETE, Mariana RACILA, Andrei COLITA, Nicoleta Mariana BERBEC, Virginia MARIN, Elena BALAN, Raluca Mihaela MANOLACHE, Doina BARBU, Silvana ANGELESCU, Oana STANCA, Anca Roxana LUPU   +12 more
doaj   +2 more sources

Total arch replacement for an aortic arch aneurysm with cold agglutinin disease after rituximab and plasmapheresis [PDF]

Journal of Cardiothoracic Surgery, 2023
Background Cold agglutinin disease can lead to significant complications, especially for patients undergoing arch repair requiring hypothermic circulatory arrest. Rituximab and plasmapheresis are treatments for cold agglutinin disease.
Atsuyuki Mitsuishi, Yujiro Miura, Kyosuke Saeki, Yoshinori Nomura, Katsumata Yoshifumi, Keisuke Yoshida   +5 more
doaj   +2 more sources

Sutimlimab for the Treatment of Cold Agglutinin Disease [PDF]

HemaSphere, 2023
Cold agglutinin disease (CAD) is a rare autoimmune hemolytic anemia and a bone marrow clonal lymphoproliferative disorder. Hemolysis in CAD is complement-dependent and mediated by the classical activation pathway.
Sigbjørn Berentsen
doaj   +2 more sources

A middle-aged woman with the initial symptom of acrocyanosis diagnosed with cold agglutinin disease: A case report [PDF]

SAGE Open Medical Case Reports
Autoimmune hemolytic anemia is when autoantibodies attack red blood cells, leading to anemia. Cold agglutinin disease, a subtype of autoimmune hemolytic anemia, accounts for 13%–32% of cases.
Babak Salimi, Maryam Salimi, Mahta Tavakoli Avval, Rona Jannati, Mohammad Negaresh   +4 more
doaj   +2 more sources

Refractory cold agglutinin disease successfully treated with daratumumab. A case report and review of literature [PDF]

Hematology, 2023
Background: Cold agglutinin disease (CAD) is immune-mediated hemolytic anemia. The disease is caused by cold reactive autoantibodies that induce hemolysis through the activation of the complement pathway.
Abdelaziz Mohamed, Mohammed Alkhatib, Awni Alshurafa, Halima El Omri   +3 more
doaj   +2 more sources

How I treat cold agglutinin disease [PDF]

Blood, 2021
AbstractThe last decades have seen great progress in the treatment of cold agglutinin disease (CAD). Comparative trials are lacking, and recommendations must be based mainly on nonrandomized trials and will be influenced by personal experience. Herein, current treatment options are reviewed and linked to 3 cases, each addressing specific aspects of ...
Sigbjørn Berentsen
openalex   +3 more sources

Anesthesia Management of Cold Agglutinin Disease in a Pregnant Patient: A Case Report [PDF]

Clinical Case Reports
Cold agglutinin disease (CAD), a rare autoimmune hemolytic anemia (AIHA), is characterized by hemolysis triggered by activation of the classical complement pathway. AIHA is estimated to affect one in 100,000 people in the general population; however, its
Jibran Ikram, Chase Jackson, Sabry Ayad
doaj   +2 more sources

Cold agglutinin disease in the setting of pancreatic adenocarcinoma [PDF]

European Journal of Case Reports in Internal Medicine
Autoimmune haemolytic anaemia (AIHA) is caused by antibody-mediated destruction of red blood cells. There are two broad categories of AIHA: warm and cold, both categorized by the thermal reactivity of the autoantibodies.
Hong Phan, Vanita Motiani, Ayema Haque, Sarrah Ali Ashgar, Harshank Patel, Zafir Zohab Hussain Khan, Susan Bannon   +6 more
doaj   +2 more sources