Results 21 to 30 of about 20,329 (253)

Iptacopan for Immune Thrombocytopenia and Cold Agglutinin Disease: A Global Phase 2 Basket Clinical Trial. [PDF]

Am J Hematol
ABSTRACT Iptacopan is a first‐in‐class, oral, selective inhibitor of complement factor B that has demonstrated positive efficacy across several complement‐driven diseases. Here we evaluate the efficacy and safety of iptacopan monotherapy in adult patients with primary immune thrombocytopenia (ITP) and primary cold agglutinin disease (CAD). We performed
Röth A, Barcellini W, Ademokun C, Jang J, Lozano ML, Ferreiras DV, Pascual-Izquierdo C, Chitnis S, Matviykiv S, Vitaliti A, Chen C, Katsanou V, Chawla R, Al-Samkari H.   +13 more
europepmc   +2 more sources

[Cold agglutinin disease (CAD)]. [PDF]

Inn Med (Heidelb)
Röth A, Borchert K, Dorn C, Kleemiß M, Körper S, Mayer S, Schafhausen P, Schrenk KG, Bramlage P, Theis F.   +9 more
europepmc   +2 more sources

Cold Agglutinins and Cryoglobulins Associate With Clinical and Laboratory Parameters of Cold Urticaria

Frontiers in Immunology, 2021
Mast cell-activating signals in cold urticaria are not yet well defined and are likely to be heterogeneous. Cold agglutinins and cryoglobulins have been described as factors possibly associated with cold urticaria, but their relevance has not been ...
Mojca Bizjak, Mitja Košnik, Dorothea Terhorst-Molawi, Dejan Dinevski, Marcus Maurer   +4 more
doaj   +1 more source

Hemolytic Anemia in the Setting of Atypical Pneumonia: A Case of Cold Agglutinin Disease. [PDF]

Cureus, 2023
Jalal Eldin A, Thomas R, Gibson G, Abongwa D, Hassan I, Tabot Tabot MK, Singh G, Sarma R.   +7 more
europepmc   +3 more sources

Congenital cardiac surgery in a patient with cold agglutinins

Current Medicine Research and Practice, 2023
Cold agglutinin disease is a type of autoimmune haemolytic anaemia caused by autoantibodies that bind to red blood cell antigens at a cold temperature and causes extravascular haemolysis and sometimes thrombosis also.
Mridul Agarwal, Reena Khantwal Joshi, Neeraj Aggarwal, Raja Joshi   +3 more
doaj   +1 more source

Necrosis secondary to cold agglutinin disease. [PDF]

CMAJ, 2022
Nakagawa H, Kato C, Miyata Y.
europepmc   +3 more sources

Sutimlimab in Cold Agglutinin Disease

New England Journal of Medicine, 2021
Cold agglutinin disease is a rare autoimmune hemolytic anemia characterized by hemolysis that is caused by activation of the classic complement pathway. Sutimlimab, a humanized monoclonal antibody, selectively targets the C1s protein, a C1 complex serine protease responsible for activating this pathway.We conducted a 26-week multicenter, open-label ...
Röth, Alexander, Barcellini, Wilma, D’Sa, Shirley, Miyakawa, Yoshitaka, Broome, Catherine M., Michel, Marc, Kuter, David J., Jilma, Bernd, Tvedt, Tor H.A., Frübis, Joachim, Jiang, Xiaoyu, Lin, Stella, Reuter, Caroline, Morales-Arias, Jaime, Hobbs, William, Berentsen, Sigbjørn   +15 more
openaire   +2 more sources

Cold agglutinin-induced hemolytic anemia during room temperature fluid resuscitation: a case report

Journal of Medical Case Reports, 2021
Background Cold agglutinin disease can cause the agglutination of red blood cells and hemolytic anemia due to cold temperature. Herein, we report a case of progressive hemolytic anemia due to cold agglutinin disease during fluid resuscitation and in the ...
Yosuke Kawai, Miyoshi Deguchi, Naoko Mizouchi, Satoru Yoshida, Ken Kumagai, Yasuo Hirose   +5 more
doaj   +1 more source

Obinutuzumab for the Treatment of Cold Agglutinin Disease: A Case Report [PDF]

Turkish Journal of Hematology
Siyuan Li, Kaini Shen, Lu Zhang
doaj   +2 more sources

Long-term safety profile of sutimlimab in adult Japanese patients with cold agglutinin disease. [PDF]

Int J Hematol
Miyakawa Y, Sato E, Ogawa Y, Nishimura JI, Nishimi M, Kawaguchi O, Tahara S, Yamaguchi M.   +7 more
europepmc   +3 more sources