Sutimlimab in Patients With Cold Agglutinin Disease (
European Journal of Haematology, EarlyView.ABSTRACT Cold agglutinin disease (CAD) is a low‐grade lymphoproliferative disorder accounting for 15%–30% of patients suffering from autoimmune hemolytic anemias. The clonal B cells produce autoantibodies primarily of the IgM‐κ class that cause agglutination of red blood cells (RBCs) at temperatures ≤ 37°C and activate the classical complement pathway ...
Sandra Maria Frey +5 more
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Cold agglutinin syndrome in a patient with human immunodeficiency virus infection
Journal of Clinical and Scientific Research, 2023 A 44-year-old female with no prior comorbidities presented with a history of easy fatiguability and yellowish discolouration of eyes of 3 months duration. On examination, she had pallor and icterus. Jugular venous pressure was elevated.
Abhilash Naini +4 more
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A novel method for negating cold agglutination interference by dithiothreitol during complete blood count and peripheral blood smear: a case study [PDF]
The Ukrainian Biochemical Journal, 2017 Cold agglutinin disease is an autoimmune disorder that is characterized by antibodies attacking polysaccharide antigens on one’s own erythrocytes.
Hamit Yasar Ellidag +2 more
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Protein glycosylation as a diagnostic and prognostic marker of chronic inflammatory gastrointestinal and liver diseases [PDF]
, 2020 Glycans are sequences of carbohydrates that are added to proteins or lipids to modulate their structure and function. Glycans modify proteins required for regulation of immune cells, and alterations have been associated with inflammatory conditions.
Callewaert, Nico +6 more
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Current Medicine Research and Practice, 2022 Cold agglutinin disease, commonly affecting females in the their seventh decade of life, is otherwise a rare entity and has an incidence of one case per million people per year.
Vivek Ranjan +4 more
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Overexpression of Nictaba-like lectin genes from glycine max confers tolerance towards Pseudomonas syringae infection, aphid infestation and salt stress in transgenic Arabidopsis plants [PDF]
, 2016 Plants have evolved a sophisticated immune system that allows them to recognize invading pathogens by specialized receptors. Carbohydrate-binding proteins or lectins are part of this immune system and especially the lectins that reside in the ...
Smagghe, Guy +2 more
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Annals of Internal Medicine: Clinical Cases, 2023 Cold agglutinin disease is a rare autoimmune hemolytic anemia that preferentially affects female patients and is more common in those older than 60 years. The pathophysiology involves IgM autoantibodies against erythrocytes in areas of the body at cooler
David Aziz +5 more
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Is Splenectomy still the best treatment for Autoimmune hemolytic anemia
Journal of Education, Health and Sport, 2023 Introduction: Autoimmune hemolytic anemia (AIHA) is an acquired, heterogeneous group of diseases that includes AIHA with warm type antibodies, cold agglutinin disease (CAD), mixed type AIHA, paroxysmal cold hemoglobinuria, and atypical AIHA ...
Malwina Chomicz +9 more
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, 2018 This article answers the question: After ordering a type and screen I was notified by the blood bank that my patient has cold autoantibodies.
Coberly, Emily, Kneib, Jessica
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Protein O-Mannosylation in the Murine Brain: Occurrence of Mono-O-Mannosyl Glycans and Identification of New Substrates [PDF]
, 2016 Protein O-mannosylation is a post-translational modification essential for correct development of mammals. In humans, deficient O-mannosylation results in severe congenital muscular dystrophies often associated with impaired brain and eye development ...
Bartels, MF +10 more
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