Results 71 to 80 of about 20,329 (253)

Cold Agglutinin Disease: A Distinct Clonal B-Cell Lymphoproliferative Disorder of the Bone Marrow

Hemato, 2022
Cold agglutinin disease (CAD) is a distinct clinicopathologic entity characterized by clonal B-cell lymphoproliferative disorder in the bone marrow. B-cell gene mutations affect NF-ΚB as well as chromatin modification and remodeling pathways.
Fina Climent, Joan Cid, Anna Sureda
doaj   +1 more source

Enhanced Immunomodulation in Inflammatory Environments Favors Human Cardiac Mesenchymal Stromal-Like Cells for Allogeneic Cell Therapies [PDF]

, 2019
Rising numbers of patients with cardiovascular diseases and limited availability of donor hearts require new and improved therapy strategies. Human atrial appendage-derived cells (hAACs) are promising candidates for an allogeneic cell-based treatment. In
Diedrichs, Falk, Haag, Marion, Jürchott, Karsten, Seifert, Martina, Sittinger, Michael, Stolk, Meaghan   +5 more
core   +1 more source

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source

Proteus sp. – an opportunistic bacterial pathogen – classification, swarming growth, clinical significance and virulence factors [PDF]

, 2013
The genus Proteus belongs to the Enterobacteriaceae family, where it is placed in the tribe Proteeae, together with the genera Morganella and Providencia. Currently, the genus Proteus consists of five species: P. mirabilis, P. vulgaris, P.
Drzewiecka, Dominika, Kwil Iwona, Maszewska Agnieszka, Moryl, Magdalena, Ostrowska Kinga, Palusiak, Agata, Różalski, Antoni, Siwinska, Malgorzata, Staçzek Paweł, Torzewska, Agnieszka, Zabłotni, Agnieszka   +10 more
core   +1 more source

Cold agglutinin disease with prolymphocytic leukemia [PDF]

Blood, 2012
A 46-year-old man presented with 2 weeks of lethargy and exertional dyspnea. Clinically he was jaundiced and had an enlarged spleen with its edge palpable at 5 cm below the left costal margin.
Richard Cheung, Yiu, Sim-Leng, Tien
openaire   +2 more sources

Mapping the Non‐Canonical Splicing Variants: Decrypting the Hidden Genetic Architecture of Idiopathic Male Infertility

Advanced Science, EarlyView.
This study highlights the significance of non‐canonical splicing variants in male infertility, a factor often overlooked during the analysis of high‐throughput sequencing data. Incorporating the non‐canonical splicing variants prioritization in the genetic analysis pipeline will increase the genetic diagnosis of patients with male infertility ...
Kuokuo Li, Yuge Chen, Dongdong Tang, Yuying Sheng, Xu Han, Hao Geng, Na Zhang, Zongliu Duan, Guanxiong Wang, Yang Gao, Rui Guo, Rong Hua, Zhiming Ding, Chuan Xu, Qunshan Shen, Zhen Yu, Bing Song, Mingrong Lv, Yuping Xu, Huan Wu, Ji Wu, Yunxia Cao, Xiaojin He   +22 more
wiley   +1 more source

Intestinal diffuse large B-cell lymphoma preceding cold agglutinin disease

Journal of Applied Hematology, 2020
Cold agglutinin disease (CAD) is a rare form of autoimmune hemolytic anemia, which shows IgM antibodies in the serum of the patient against red blood cell antigens, showing maximal reactivity at 4°C.
Kapil Goyal, Roopa Sharma, Sandeep Garg
doaj   +1 more source

Coronavirus Disease 2019 and Cold Agglutinin Syndrome: An Interesting Case

European Journal of Case Reports in Internal Medicine, 2021
The coronavirus disease 2019 (COVID-19) pandemic has caused significant morbidity and mortality worldwide. While patients with COVID-19 most frequently present with pneumonia, respiratory failure and acute respiratory distress syndrome, increasing cases ...
Ruby Gupta, Sukhmani Singh, Nwabundo Anusim, Sachin Gupta, Sorab Gupta, Marianne Huben, George Howard, Ishmael Jaiyesimi   +7 more
doaj   +1 more source

Glyco-functionalised quantum dots and their progress in cancer diagnosis and treatment [PDF]

, 2020
Despite all major breakthroughs in recent years of research, we are still unsuccessful to effectively diagnose and treat cancer that has express and metastasizes.
Ashree, Jayshree, Chao, Yimin, Wang, Qi
core   +1 more source

EIF5A Couples Translational Control With Transcriptional Reprogramming Through Chromocenter Reorganization During Spermiogenesis

Advanced Science, EarlyView.
The translation factor Eukaryotic translation initiation factor 5A (eIF5A) is essential for male fertility in mice. It supports the translation of proteins crucial for heterochromatin organization and acrosome formation. eIF5A deficiency disrupts chromocenter integrity, increases chromatin accessibility, and causes transcriptional dysregulation ...
Yuling Cai, Tongtong Li, Qian Fang, Ziyou Bao, Feng Kong, Huitao Qi, Hanzhen Li, Mingyu Zhang, Wei Wang, Yongxia Guan, Wenbo Liu, Xiangfeng Chen, Zi‐Jiang Chen, Xiaohua Jiang, Xin Wang, Hongbin Liu   +15 more
wiley   +1 more source