Results 11 to 20 of about 21,259 (190)

Content of Th17 related and Th2 cytokines in asthma patients with cold airway hyperresponsiveness

Медицинская иммунология
The phenomenon of cold airway hyperresponsiveness is rather common among patients with bronchial asthma. Possible participation of immune mechanisms in its occurence is scarcely studied.
A. B. Pirogov, A. G. Prikhodko, N. A. Pirogova, D. E. Naumov, D. A. Gassan, J. M. Perelman   +5 more
doaj   +5 more sources

Efficiency of using a short-acting β2-agonist for the relief of acute cold bronchospasm in asthma patients with cold airway hyperresponsiveness

Сибирский научный медицинский журнал, 2022
Excessive sensitivity of the respiratory tract to physical and chemical environmental triggers can vary for many reasons, reducing the therapy effectiveness in a patient with asthma. Aim of the study was to investigate the effectiveness of a short-acting
A. G. Prihodko, J. M. Perelman
doaj   +5 more sources

Exacerbation of asthma and neutrophil-dominated airway inflammation in patients with cold-induced airway hyperresponsiveness

Бюллетень сибирской медицины, 2021
Background. Neutrophils can play a significant role in the formation of bronchial inflammation in asthma  exacerbation in patients with cold-induced airway hyperresponsiveness (CIAHR).Aim.
A. B. Pirogov, A. G. Prikhodko, E. Yu. Afanaseva, E. G. Sheludko, Ya. G. Gorchakova, X. Zhou, Q. Li, Yu. M. Perelman   +7 more
doaj   +4 more sources

Destruction of the bronchial epithelium in patients with severe asthma according to different patterns of inflammation and cold airway hyperresponsiveness [PDF]

Терапевтический архив, 2019
The aim of the research was to study the state of the bronchial mucosa epi-thelium in relation to the severity of clinical manifestations in severe uncon-trolled asthma depending on the pattern of inflammation and the presence of cold airway ...
A B Pirogov, D A Gassan, S S Zinov’ev, A G Prikhodko, V P Kolosov, J M Perelman   +5 more
doaj   +5 more sources

Bronchial granulocytes in the development of epithelial destruction and oxidative lipid modification in patients with bronchial asthma with cold and osmotic airway hyperresponsiveness

Сибирский научный медицинский журнал, 2021
Free radical damage to the respiratory tract in patients with asthma leads to the destruction of the bronchial parenchyma and the generation of signaling molecules of inflammation by parenchymal cells.
A. B. Pirogov, A. G. Prikhodko, Ju. M. Perelman   +2 more
doaj   +4 more sources

ROLE OF TRPM8 GENE POLYMORPHISMS IN THE FORMATION OF ASTHMA PHENOTYPE WITH COLD AIRWAY HYPERRESPONSIVENESS

Bulletin physiology and pathology of respiration, 2017
The aim of the study was to evaluate the effect of TRPM8 cold thermoreceptor gene polymorphisms on the development of asthma phenotype with cold airway hyperresponsiveness (CAH). 167 cases of mild-to-moderate persistent asthma were retrospectively analyzed. In each case, the examination included two repeated bronchoprovocation tests with 3-min isocapic
Viktor Kolosov, Yuliy Perelman, Anna Prikhodko, Dina Gassan, Olesya Kotova, Denis Naumov   +5 more
core   +6 more sources

Interleukin-4 and interferon gamma in bronchial remodeling in asthma patients with cold airway hyperresponsiveness

Бюллетень сибирской медицины
Interleukin-4 (IL-4) and interferon gamma (IFNγ) are key participants in the polarization of the immune response toward Th1 or Th2 types in bronchial asthma.
A. B. Pirogov, A. G. Prikhodko, N. A. Pirogova, D. A. Gassan, D. E. Naumov, J. M. Perelman   +5 more
doaj   +3 more sources

FEATURES OF STRUCTURAL ORGANIZATION OF GOBLET EPITHELIUM OF BRONCHI IN ASTHMA PATIENTS WITH COLD AIRWAY HYPERRESPONSIVENESS

Bulletin physiology and pathology of respiration, 2018
In 46 patients with mild persistent asthma the collection and cytological study of the induced sputum (IS) was done to assess the inflammatory pattern of bronchi, structural organization of bronchial epithelium and secretory goblet cells; the level of the disease control by the data of the validated questionnaire Asthma Control Test was found out; the ...
Ci Li, Xiangdong Chzhou, Yuliy Perelman, Anna Prikhodko, Sergey Zinovev, Aleksey Pirogov   +5 more
core   +4 more sources

THE CHANGE OF GOBLET CELLS IN RESPONSE TO COLD BRONCHIAL CHALLENGE IN PATIENTS WITH BRONCHIAL ASTHMA WITH COLD AIRWAY HYPERRESPONSIVENESS

Bulletin physiology and pathology of respiration, 2018
Destruction of bronchial epithelium in patients with bronchial asthma (BA) is at the bottom of the mechanism of epithelial dysfunction, mucociliary insufficiency and bronchial remodeling. The aim of the work is to assess the character of changes that happen in the structural organization of cell elements and secretory activity of bronchial goblet ...
Ci Li, Xiangdong Chzhou, Sergey Zinovev, Yuliy Perelman, Anna Prikhodko, Aleksey Pirogov   +5 more
core   +4 more sources

The influence of smoking on the formation of airway hyperresponsiveness to cold and the course of destructive-cytological processes in the goblet cells of the bronchial epithelium in patients with asthma

Бюллетень сибирской медицины, 2019
Tobacco smoking in patients with asthma can intensify the bronchi mucosa damage and significantly worsen the course of the disease.Aim. To assess the influence of tobacco smoking on the clinical manifestations of the disease, airway response to cold air ...
A. B. Pirogov, A. G. Prikhodko, V. P. Kolosov, Ju. M. Perelman   +3 more
doaj   +4 more sources