Results 211 to 220 of about 68,073 (265)

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

From Design to Bioactivity: 2-Benzoylpyridine 4-(bicyclo[2.2.1]hept-2-yl)thiosemicarbazone and Its 3d Metal Coordination Compounds. [PDF]

ChemistryOpen
Graur I, Graur V, Melnic E, Lozan-Tirsu C, Balan G, Tsapkov V, Gulea A.   +6 more
europepmc   +1 more source

Intravital Multimodal Imaging of Human Cortical Organoid Transplantation in a Mouse Model of Chronic Stroke

Advanced Science, EarlyView.
A multimodal intravital imaging platform enables longitudinal tracking of human cortical organoids transplanted into chronic stroke lesions. By combining surgical microscopy, MRI, bioluminescence imaging, and two‐photon fluorescence microscopy, the platform captures graft placement, viability dynamics, and cellular‐scale morphology in vivo, offering a ...
Jinghui Wang, Guanda Qiao, Honglin Tan, Colleen Russel, Baixuan Yang, Mengyang Jacky Li, Kexin Wang, Jiadi Xu, Chengyan Chu, Miroslaw Janowski, Tian‐Ming Fu, Piotr Walczak, Yajie Liang   +12 more
wiley   +1 more source

Single-Metal-Atom Chains at Mirror Twin Boundaries in Transition Metal Dichalcogenides: Electronic, Magnetic, and Catalytic Properties. [PDF]

ACS Appl Mater Interfaces
Santra P, Ghorbani-Asl M, Jolie W, Krasheninnikov AV.   +3 more
europepmc   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

First-Principles Investigation of Glucose Adsorption and Sensing-Related Electronic Modulation on Ti₃C₂O₂ MXene. [PDF]

Micromachines (Basel)
Rafiq M, Lu B, Matteini P, Wu Y, Hwang B, Lim S.   +5 more
europepmc   +1 more source

Atom camera: super-resolution scanning microscope of a light pattern with a single ultracold atom. [PDF]

Nat Commun
Tomita T, Chew YT, Villela RA, Mahesh TP, Sakai H, Nishimura K, Ando T, de Léséleuc S, Ohmori K.   +8 more
europepmc   +1 more source

Ultrahigh strength magnesium via solidification of nanocolloid. [PDF]

Nat Commun
Yang X, Nadendla HB, Fang C, Nishi S, Matsuda T, Kambara M, Tanaka T, Dougakiuchi M, Tang F, West GD, Wang S, Ramasse QM.   +11 more
europepmc   +1 more source

Large and ultra-flat optical traps for uniform quantum gases. [PDF]

Sci Rep
Frye-Arndt K, Glaysher M, Rhyno B, Glaeser M, Koch M, Seckmeyer S, Ahlers H, Herr W, Gaaloul N, Schubert C, Rasel EM.   +10 more
europepmc   +1 more source

Proton-Initiated Reversible Chalcogen-Vertex Extrusion in Macropolyhedral Chalcogenaboranes. [PDF]

Inorg Chem
Bould J, Litecká M, Clegg W, Ehn M, Kennedy JD, Londesborough MGS.   +5 more
europepmc   +1 more source