Results 221 to 230 of about 49,019 (247)

Effects of Glutamine Supplementation and Early Cold Conditioning on Cold Stress Adaptability in Broilers. [PDF]

Animals (Basel)
Al-Khalaifah H, Tolba SA, Al-Nasser A, Gouda A.   +3 more
europepmc   +1 more source

MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the role of MAGEA6 in perineural invasion (PNI) in colorectal cancer (CRC). MAGEA6 promotes CRC invasiveness by inhibiting YY1 ubiquitination, enhancing CXCL1 secretion, and recruiting Schwann cells. These findings highlight the potential of targeting the MAGEA6/YY1/CXCL1 axis for therapeutic strategies against PNI and tumor ...
Hao Wang, Kexin He, Ruixue Huo, Weihan Li, Shan Zhang, Lu‐Ju Jiang, Hao Wu, Minhao Yu, Shu‐Heng Jiang, Junli Xue   +9 more
wiley   +1 more source

Trends in population exposure to compound extreme-risk temperature and air pollution across 35 European countries: a modelling study.

Lancet Planet Health
Chen ZY, Achebak H, Petetin H, Méndez Turrubiates RF, Guo Y, Pérez García-Pando C, Ballester J.   +6 more
europepmc   +1 more source

Microbiome Adaptation Could Amplify Modeled Projections of Global Soil Carbon Loss With Climate Warming. [PDF]

Glob Chang Biol
Abs E, Saleska SR, Allison SD, Ciais P, Song Y, Weintraub MN, Ferriere R.   +6 more
europepmc   +1 more source

Locus Coeruleus Noradrenergic‐Spinal Projections Contribute to Electroacupuncture‐Mediated Antinociception in Postoperative Pain in Mice

Advanced Science, EarlyView.
How locus coeruleus noradrenergic‐spinal projections and subsequent α2A adrenoceptors‐CaMKII signaling cascades contribute to electroacupuncture‐induced antinociception in postoperative pain in mice is described. Abstract Postoperative pain remains a significant challenge in healthcare.
Wen‐Guang Chu, Ru Zhang, Hai‐Tao Li, Ying‐Chun Li, Hui Ding, Zhen‐Zhen Li, Wen‐Juan Han, Fei Wang, Xing‐Xing Zheng, Hong‐Hui Mao, Hua Yuan, Sheng‐Xi Wu, Rou‐Gang Xie, Ceng Luo   +13 more
wiley   +1 more source

Climate-driven succession in marine microbiome biodiversity and biogeochemical function. [PDF]

Nat Commun
Larkin AA, Brock ML, Fagan AJ, Moreno AR, Gerace SD, Lees LE, Suarez SA, Eloe-Fadrosh EA, Martiny AC.   +8 more
europepmc   +1 more source

Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera

Advanced Science, EarlyView.
The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang, Xinyu Qiu, Xiaoning Tong, Shaoju Gan, Weicheng Yi, Sitao Xie, Xiangsheng Liu, Chao Zuo, Weihong Tan   +8 more
wiley   +1 more source

Detection of single-mode thermal microwave photons using an underdamped Josephson junction. [PDF]

Nat Commun
Pankratov AL, Gordeeva AV, Chiginev AV, Revin LS, Blagodatkin AV, Crescini N, Kuzmin LS.   +6 more
europepmc   +1 more source

NDRG1‐Driven Lactate Accumulation Promotes Lung Adenocarcinoma Progression Through the Induction of an Immunosuppressive Microenvironment

Advanced Science, EarlyView.
NDRG1 drives lactate accumulation and histone lactylation in lung adenocarcinoma, promoting immunosuppression via M2 macrophage polarization and CD8⁺ T cell inhibition. High NDRG1 expression correlates with poor prognosis, an immunosuppressive microenvironment, and immunotherapy resistance.
Gujie Wu, Hongxia Cheng, Jiacheng Yin, Yuansheng Zheng, Haochun Shi, Binyang Pan, Ming Li, Mengnan Zhao, Jiaqi Liang, Yunyi Bian, Guangyao Shan, Guoshu Bi, Weigang Guo, Lin Wang, Yiwei Huang   +14 more
wiley   +1 more source

Obesity accelerates age-related memory deficits and alters white matter tract integrity in Ldlr-/-.Leiden mice. [PDF]

Brain Behav Immun Health
Seidel F, Morrison MC, Arnoldussen I, Verweij V, Attema J, de Ruiter C, van Duyvenvoorde W, Snabel J, Geenen B, Franco A, Wiesmann M, Kleemann R, Kiliaan AJ.   +12 more
europepmc   +1 more source