Results 251 to 260 of about 678,119 (336)

Single‐Cell RNA Sequencing of Retina Reveals Nna1 Upregulation in Myopic Diabetic Retinopathy as a Protective Factor Against Diabetic Damage

Advanced Science, EarlyView.
This study investigates a schematic overview of the mechanistic pathways. The relationship between myopia and DR has long been of clinical interest. In diabetic mice, Nna1 expression is downregulated, whereas in diabetic mice with FDM, Nna1 expression is upregulated–particularly in Müller cells–accompanied by decreased vascular endothelial growth ...
Lihui Xie, Yingjun Cai, Bolin Chen, Bowen Li, Jing Zou, Huizhuo Xu   +5 more
wiley   +1 more source

Some Like It Rock 'N' Cold: Speleomycology of Ravništarka Cave (Serbia). [PDF]

J Fungi (Basel)
Stupar M, Savković Ž, Pećić M, Jerinkić D, Jakovljević O, Popović S.   +5 more
europepmc   +1 more source

Inhibiting Liver‐Derived C3 Protein Rescues Anesthesia/Surgery‐Induced Cognitive Impairment, Synaptic Disorders, and Microglial Phagocytosis

Advanced Science, EarlyView.
This study provides evidence that anesthesia/surgery can induce the BBB breakdown and promote the release of hepatogenous C3 protein into the blood. This surgical dual factors ultimately drove C3 to cross the damaged BBB and selectively colocalize with C3aR in the hippocampus, which results in structural and functional injury of synapse, C3aR‐mediated ...
Qianqian Wu, Peilin Cong, Zhouxiang Li, Yuxin Zhang, Huanghui Wu, Qian Zhang, Yawei Li, Li Tian, Qingyuan Miao, Yinggang Zheng, Hui Zhang, Qian Chen, Enduo Feng, Xinyang Li, Zheping Chen, Dong‐Xin Wang, Xinwei Huang, Lize Xiong   +17 more
wiley   +1 more source

Minor contribution of ammonia oxidizers to inorganic carbon fixation in the ocean. [PDF]

Nat Geosci
Bayer B, Kitzinger K, Paul NL, Albers JB, Saito MA, Wagner M, Carlson CA, Santoro AE.   +7 more
europepmc   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

Effects of low temperature stress on photosynthetic characteristics and antioxidant defense system of flue-cured tobacco. [PDF]

Front Plant Sci
Din NU, Ye W, Chen J, Deng S, Zhong X, Chen Y.   +5 more
europepmc   +1 more source

Latest Results From The CDMS-II Cold Dark Matter Search

, 2006
P. L. Brink, D. S. Akerib, M. S. Armel‐Funkhouser, M. J. Attisha, C. N. Bailey, L. Baudis, D. Bauer, R. Bunker, B. Cabrera, D. O. Caldwell, C. L. Chang, M. B. Crisler, P. Cushman, M. Daal, R. Dixon, M. R. Dragowsky, D. D. Driscoll, L. Duong, R. Ferril, J. P. Filippini, R. J. Gaitskell, R. Hennings‐Yeomans, D. Holmgren, M. E. Huber, S. Kamat, A. Lu, R. Mahapatra, V. Mandic, John M. Martinis, P. Meunier, N. Mirabolfathi, H. Nelson, R. Nelson, R. W. Ogburn, T. A. Perera, E. Ramberg, A. Reisetter, R. R. Ross, T. Saab, B. Sadoulet, J. Sander, Carl Savage, R. W. Schnee, D. N. Seitz, B. Serfass, K. M. Sundqvist, J.-P.F. Thompson, G. Wang, S. Yellin, Betty Young   +49 more
openalex   +2 more sources

PHR‐Mediated Pi Starvation Response Mobile Messenger RNAs Represent Noncoding Transcripts in Recipient Tissues

Advanced Science, EarlyView.
Mobile messenger RNAs (mRNAs) can travel long distances, serving as systemic signals that participate in plant growth and stress acclimation. This work determines that PHR proteins mediate the Pi starvation response (PSR)‐specific long‐distance transport of mRNAs and that these PSR‐specific mobile mRNAs represent noncoding transcripts in recipient ...
Weiguo Dong, Shuman Wang, Chao Liu, Lulu Qiao, Kai Liu, Qiongli Jin, Xiaorong Mo, Xingxing Shen, Keke Yi, Zhiye Wang   +9 more
wiley   +1 more source

Thermal regimes during overwintering recovery shape microbial network and dissolved organic matter complexity in Microcystis-dominated systems. [PDF]

ISME J
Liu Y, Xie Z, Feng J, Xie S, Ma C.
europepmc   +1 more source

Discovery of a Potent and Selective TEAD Degrader with Durable Degradation Activity

Advanced Science, EarlyView.
KG‐FP‐003, a highly potent TEAD‐YAP PROTAC derived from the patented inhibitor is developed. It selectively degrades endogenous TEAD proteins in HiBiT systems without IMiD‐related off‐target effects. Screening across 867 cancer cell lines revealed broad and superior anti‐tumor activity, highlighting its therapeutic potential through targeted TEAD ...
Linhui Cao, Jing Yang, Yuhang Liu, Xiaotong Chen, Yufang Shi, Yunshuo Zhao, Yong Zhang, Jian Chen, Bowen Li, Wuqiang Wen, Lu Chen, Bo Peng, Lu Huang, Yanli Sun, Lixin Zhou, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Zhixiang Guo, Jing Xing, Guangya Zhu, Yazhou Wang, Baishan Jiang, Jing Lu, Kehao Zhao, Wenchao Lu   +25 more
wiley   +1 more source