Results 31 to 40 of about 260,144 (267)

A Review on Galling of Aluminum in Cold Forming Processes

open access: yesDüzce Üniversitesi Bilim ve Teknoloji Dergisi
As world’s sustainability become the most influential topic, aluminum and its alloys are becoming the preferred material of the automotive industry because they allow vehicle weight to be reduced without compromising safety.
Hatice Sandallı, Mert Özdoğan
doaj   +1 more source

Experimental Research on the Cold-Forming Effect of Cold-Formed Thick-Walled Steel

open access: yesBuildings, 2023
To study the cold-forming effect on the yield strength distribution of cold-formed thick-walled steel, material tensile tests and axial compression tests were conducted on steel-lipped channels. To undertake the material tensile tests, five types of cold-formed lipped channel sections with varied thicknesses and nominal yield strengths were selected ...
Xiaochao Fu   +3 more
openaire   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Probing the potential of structured and surface functionalized tools for dry cold forging of aluminium

open access: yesMATEC Web of Conferences, 2018
In order to reduce friction and wear in cold forging of aluminium and its alloys a tremendous amount of lubricants is used. The main task of the liquid lubricants is the separation of tool and workpiece surfaces to avoid adhesion and abrasion.
Teller Marco   +7 more
doaj   +1 more source

Forming of Components with Microgearings from Coil Material—Numerical Modeling of the Process Chain and Experimental Validation

open access: yesMicromachines, 2021
Compared to alternative production methods, cold forming offers technological, economic and ecological potential for the mass production of microgears.
Andreas Rohrmoser   +2 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Soğuk Dövme Prosesi ile 20MnB4 Hammadde Kullanılarak Üretilen Cıvatanın Isıl İşlem Şartlarının Metalografik ve Mekanik Özelliklere Olan Etkisinin İncelenmesi

open access: yesDüzce Üniversitesi Bilim ve Teknoloji Dergisi, 2018
Civataüretiminin kritik prosesi olan ısıl işlem prosesi; soğuk şekillendirilenmalzemenin metalografik ve mekanik özelliklere olan etkisinin araştırılması,hem proses verimi hemde ürün performans kriterleri açısındandeğerlendirildiğinde sektörde deneysel ...
ALPER Baygut   +2 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Correlating Ultrasonic Velocity in DC04 with Microstructure for Quantification of Ductile Damage

open access: yesJournal of Manufacturing and Materials Processing, 2023
The detection of ductile damage by image-based methods is time-consuming and typically probes only small areas. It is therefore of great interest for various cold forming processes, such as sheet-bulk metal forming, to develop new methods that can be ...
Steffen Wackenrohr   +4 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

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